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Diss Factsheets
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EC number: 233-046-7 | CAS number: 10025-87-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- SIDS INITIAL ASSESSMENT PROFILE for Phosphoric acid
- Author:
- SIDS
- Year:
- 2 009
- Bibliographic source:
- https://hpvchemicals.oecd.org/ui/handler.axd?id=0c142f1e-37eb-404d-90ac-be4a9f440ebd
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- Principles of method if other than guideline:
- The reproductive toxicity of phosphoric acid has been investigated in a reproductive and developmental toxicity screening test in rats [OECD TG 422]. In this study, phosphoric acid was administered via gavage to 13 of animals/sex/dose, concentration at 0, 125, 250 and 500 mg/kg bw/day, for 2 weeks. Based on results of reproductive and development toxicity, no treatment-related effects were observed. At 500 mg/kg bw/day, 2/13 adult females died, indicating parental toxicity at this dose. No effects of test substance were observed on mating, conception, parturition and external of neonates, neonate body weights, and survival rate. Therefore, NOAEL for reproductive and development toxicity was estimated to be 500 mg/kg bw/day, the highest dose tested.
- GLP compliance:
- not specified
- Remarks:
- Secondary source
- Limit test:
- no
Test material
- Reference substance name:
- Orthophosphoric acid
- EC Number:
- 231-633-2
- EC Name:
- Orthophosphoric acid
- Cas Number:
- 7664-38-2
- Molecular formula:
- H3O4P
- IUPAC Name:
- phosphoric acid
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- 2 weeks.
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 mg/kg bw/day
- Dose / conc.:
- 125 mg/kg bw/day
- Dose / conc.:
- 250 mg/kg bw/day
- Dose / conc.:
- 500 mg/kg bw/day
- No. of animals per sex per dose:
- 13 animals/sex/dose
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Key result
- Effect level:
- 500 mg/kg bw/day
- Remarks on result:
- other: At 500 mg/kg bw/day, 2/13 adult females died, indicating parental toxicity at this dose.
Target system / organ toxicity (P0)
- Critical effects observed:
- yes
- Lowest effective dose / conc.:
- 500 mg/kg bw/day (nominal)
- System:
- other: Parental toxicity
- Organ:
- not specified
- Treatment related:
- yes
- Dose response relationship:
- yes
Results: F1 generation
Details on results (F1)
Effect levels (F1)
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 500 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: Reproductive and development toxicity
- Remarks on result:
- other: Therefore, NOAEL for reproductive and development toxicity was estimated to be 500 mg/kg bw/day, the highest dose tested.
Target system / organ toxicity (F1)
- Critical effects observed:
- no
Overall reproductive toxicity
- Reproductive effects observed:
- no
Any other information on results incl. tables
Based on results of reproductive and development toxicity, no treatment-related effects were observed.
Applicant's summary and conclusion
- Executive summary:
The reproductive toxicity of phosphoric acid has been investigated in a reproductive and developmental toxicity screening test in rats [OECD TG 422]. In this study, phosphoric acid was administered via gavage to 13 of animals/sex/dose, concentration at 0, 125, 250 and 500 mg/kg bw/day, for 2 weeks. Based on results of reproductive and development toxicity, no treatment-related effects were observed. At 500 mg/kg bw/day, 2/13 adult females died, indicating parental toxicity at this dose. No effects of test substance were observed on mating, conception, parturition and external of neonates, neonate body weights, and survival rate. Therefore, NOAEL for reproductive and development toxicity was estimated to be 500 mg/kg bw/day, the highest dose tested.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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