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EC number: 233-046-7 | CAS number: 10025-87-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- other: Direct observations, poisoning incidents
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Risk assessment, direct observations, poisoning incidents
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Phosphoroxidchlorid [MAK Value Documentation in German language, 1984]
- Author:
- MAK
- Year:
- 1 984
- Bibliographic source:
- Wiley-VCH Verlag, The MAK Collection for Occupational Health and Safety, 1-10.
- Reference Type:
- publication
- Title:
- Vergleichende Toxizität von Phosphor-Chlorverbindungen (POCl3, PCl3, PCl5) bei einmaliger und wiederholter Exposition [Comparative toxicity of the chloride compounds of phosphorus (POCl3, PCl3, PCl5) in single and repeated exposures]
- Author:
- Molodkina NN
- Year:
- 1 974
- Bibliographic source:
- Nov Prom Khim Veshch, 13, 107-114
- Reference Type:
- publication
- Title:
- Peculiarities of the biological action exerted by phosphorus oxychloride
- Author:
- Molodkina NN
- Year:
- 1 971
- Bibliographic source:
- Gigiena Truda i Professional'nye Zabolevaniia, 10, 30-34
- Reference Type:
- publication
- Title:
- Intoxication collective professionelle par l'oxychlorure de phosphore [Collective occupational intoxication by phosphorus oxychloride]
- Author:
- Oltramare M, Bahy M, Desbaumes P, Voinier B
- Year:
- 1 975
- Bibliographic source:
- Archives des Maladies Professionelles de Medecine du Travail et de Securite Sociale, 36, 438-440
- Reference Type:
- publication
- Title:
- Malattie causate da fosforo e composti [Illnesses caused by phosphorus and compounds]
- Author:
- Parmeggiani L
- Year:
- 1 953
- Bibliographic source:
- Medicina del Lavoro, 44, 263-265
- Reference Type:
- publication
- Title:
- Le syndrome de dysfonction reactive des voies aeriennes; une forme particulere d'asthma professionnel
- Author:
- Rivoire B, Carre P, Lasfragues G, Moline J, Lavandier M
- Year:
- 1 996
- Bibliographic source:
- Archives des Maladies Professionnelles et de Medicine de Travail, 57, 136
- Reference Type:
- publication
- Title:
- Poisoning caused by inhalation of hydrogen chloride, phosphorus oxychloride, phosphorus pentachloride, oxalic acid
- Author:
- Rosenthal T, Baum GL, Frand U, Molho M
- Year:
- 1 978
- Bibliographic source:
- Chest 73 (5), 623-626
- Reference Type:
- publication
- Title:
- Chloro compounds of phosphorus as industrial hazards.
- Author:
- Roshchin AV, Molodkina NN
- Year:
- 1 977
- Bibliographic source:
- Journal of Hygiene, Epidemiology, Microbiology and Immunology, 21(4), 387-394.
- Reference Type:
- publication
- Title:
- Contributo clinico alla conoscenza dell' intossicazione acuta da ossicloruro di fosforo
- Author:
- Scotti P
- Year:
- 1 967
- Bibliographic source:
- Minerva Medica, 58, 129-131
- Reference Type:
- publication
- Title:
- Recent occupational diseases in Japan
- Author:
- Tati M
- Year:
- 1 988
- Bibliographic source:
- Asian medical journal 31, 301-307
Materials and methods
- Type of study / information:
- Risk assessment, direct observations, poisoning incidents in humans
- Endpoint addressed:
- respiratory irritation
- Principles of method if other than guideline:
- Risk assessment, direct observations, poisoning incidents
Test material
- Reference substance name:
- Phosphoryl trichloride
- EC Number:
- 233-046-7
- EC Name:
- Phosphoryl trichloride
- Cas Number:
- 10025-87-3
- Molecular formula:
- Cl3OP
- IUPAC Name:
- phosphoroyl trichloride
Constituent 1
Method
- Details on study design:
- Risk assessment, direct observations, poisoning incidents in humans
Results and discussion
- Results:
- Phosphoryl trichloride is a severely corrosive, colorless liquid of pungent odor. In contact with water, humid air or water containing liquids phosphoryl trichloride reacts to produce heat, phosphoric acid, and hydrochloric acid. A marked irritation to mucous membranes of eyes and respiratory tract is the most pronounced effect.
The moderate solubility in water may cause a delay of the start of reaction and enable phosphoryl trichloride to reach the deeper parts of the respiratory tract.
Additionally irritation is only weak at the beginning and sign of intoxication develop within several hours. These properties produce little warning at the start of exposure and severe, long-lasting effects can arise.
Symptoms after acute exposure are: reddening of mucous membranes, inflammation of eyes, lacrimation, dry cough, dyspnea, corrosion of airways, lung edema. Additionally headache, nausea, fatigue, vomiting were reported. Long term effects: obstructive lung disease, increased sensitivity to irritants and infection.
Long term, low level exposure can produce liver and kidney changes, changes in bone structure and mutagenic effects in animals.
Direct skin contact causes all stages of irritation and corrosion depending on duration and the presence of water at the site of exposure. Similar effects occur in the digestive tract after ingestion.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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