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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 700-991-6 | CAS number: 8007-24-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Dermal absorption
Administrative data
- Endpoint:
- dermal absorption, other
- Type of information:
- other: Expert review and assessment derived from available information
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Expert review of available data
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-[(7Z)-pentadec-7-en-1-yl]phenol; 3-[(7Z,10Z)-pentadeca-7,10,14-trien-1-yl]phenol; 3-[(7Z,10Z)-pentadeca-7,10-dien-1-yl]phenol; 3-pentadecylphenol
- EC Number:
- 700-991-6
- Cas Number:
- 8007-24-7
- Molecular formula:
- Cardanol (saturated side chain): Formula: C21 H36 O Cardanol (monoene): Formula: C21 H34 O Cardanol (diene): Formula: C21 H32 O Cardanol (triene): Formula: C21 H30 O
- IUPAC Name:
- 3-[(7Z)-pentadec-7-en-1-yl]phenol; 3-[(7Z,10Z)-pentadeca-7,10,14-trien-1-yl]phenol; 3-[(7Z,10Z)-pentadeca-7,10-dien-1-yl]phenol; 3-pentadecylphenol
Constituent 1
Results and discussion
- Absorption in different matrices:
- The rate and extent of absorption cannot be elucidated from the data available.
Any other information on results incl. tables
There are no toxicokinetic studies that have directly addressed the absorption, distribution, metabolism, or excretion of Distilled Grade. However, information on these processes have been inferred based upon the properties of the chemical and the results of reliable and relevant short- and longer-term mammalian toxicity tests based on guidance given in ECHA (2017).sed the absorption, distribution, metabolism, or excretion of Distilled Grade. However, information on these processes have been inferred based upon the properties of the chemical and the results of reliable and relevant short- and longer-term mammalian toxicity tests based on guidance given in ECHA (2017).
The only likely route of absorption of the different constituents of Distilled Grade is via dermal exposure due to the industrial use patterns of the test substance identified in the Risk Characterisation Exercise. However, the lipophilicity of the different forms of cardanol (estimated log Kow values >8.31for all forms) and their molecular weights (298 to 304 g/mole) means that the expected rate of transfer of substances between the stratum corneum (the non-viable layer of corneocytes forming a complex lipid membrane that must be first penetrated) and the epidermis (which is resistant to penetration by highly lipophilic substances) will be slow and will limit absorption across the skin. In addition uptake of the Distilled Grade constituents into the stratum corneum itself may also be slow unless any damage to the skin surface caused by Distilled Grade (an identified irritant) enhances penetration (ECHA, 2017).Grade constituents into the stratum corneum itself may also be slow unless any damage to the skin surface caused by Distilled Grade (an identified irritant) enhances penetration (ECHA, 2017). Evidence for limited skin absorption is provided by an Acute Dermal Toxicity study (OECD TG402) where Wistar rats that were exposed to a single dose of 2000 mg/ kg body weight for 24 hours showed no signs of systemic toxicity throughout the 14-day observation period. Signs of systemic toxicity would be an indication that absorption has occurred. At the end of the test all animals were subjected to an external examination and opening of the abdominal and thoracic cavities. No abnormalities were noted at necropsy.
Applicant's summary and conclusion
- Conclusions:
- There are no toxicokinetic studies that have directly addressing the dermal absorption of Distilled Grade. Based on the lipophilicity of the different forms of cardanol (estimated log Kow values >8.31for all forms) and their molecular weights (298 to 304 g/mole), the expected rate of transfer of substances between the stratum corneum and the epidermis (which is resistant to penetration by highly lipophilic substances) will be slow and will limit absorption across the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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