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Diss Factsheets
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EC number: 265-745-8 | CAS number: 65405-77-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Skin irritation: The test material was found to be non-irritating to human skin at concentrations of 2, 6 and 12% in EtOH/DEP 1:1, single application patch test under occlusion, Küster & Goluchowski (1999)
Skin sensitisation: Not sensitising at concentrations of 8 and 15 % in EtOH/DEP 1:1 in a human repeat insult patch test under occlusive conditions, Middeke & Küster (2000)
Skin sensitisation: Not sensitising in a human maximisation test, Kligman (1975)
Additional information
The skin irritation potential of the test material was assessed in 50 human volunteers using a single application patch test. Test material at concentrations of 2, 6 and 12% in EtOH/DEP 1:1 was applied to the back of each volunteer under occlusive cutaneous test plasters. After a test period of 48 hours the test plasters were removed and the test area was assessed. Further assessments were performed after 72 and 96 hours. With the exception of two slight reactions noted in the 2% product, the test material was found to be well tolerated by the skin under the conditions of the study.
The skin sensitisation potential of hexenyl-3-cis salicylate was assessed in 50 volunteers using repeated application closed patch epicutaneous testing under occlusion. Informed written consent was sought prior to study initiation. The test material was found to be very well tolerated by the skin under the conditions of the test at 8% and 15% concentrations in EtOH/DEP 1:1.
Supporting information on the skin sensitisation potential of the test material, in humans, is available in the form of a report by Kligman (1975). The report documents results of a patch test during which the test material was applied under occlusion to the forearms of 25 adult volunteers for five alternate day 48 hour periods. The patch sites was pre-treated for 24 hours with 5% aqueous sodium lauryl sulfate under occlusion. The challenge sites were read on removal of the patch and 24 hours thereafter. Under the conditions of the study, there were no instances of contact-sensitisation from the test material on the Maximisation Test. It is unlikely that this test material would present a danger of contact-sensitisation in normal, intended use.
All studies were presented in a sufficient level of detail to assess accuracy of the conclusions presented. All studies were performed in line with good scientific principles. The data were therefore all assigned a reliability score of 2 in accordance with the principles for assessing data quality described by Klimisch (1997).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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