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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 265-745-8 | CAS number: 65405-77-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.59 mg/m³
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Dose descriptor starting point:
- NOAEL
- Value:
- 180 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 159 mg/m³
- Explanation for the modification of the dose descriptor starting point:
NOAEL(oral) converted to NOAEC(inhal) (180 mg/kg x [1/0.38 x 50% oral absorption rat/100% inhalation absorption human x 6.7/10]) = 159 mg/m3
- AF for dose response relationship:
- 1
- Justification:
- Default value in line with Section R.8.4.3.1 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for differences in duration of exposure:
- 2
- Justification:
- Extrapolation from subchronic study to chronic exposure value in line with Table R.8-5 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Not applied as differences in the allometry are assumed to be compensated by differences in the respiration rate.
- AF for other interspecies differences:
- 2.5
- Justification:
- Default value in line with Section R.8.4.3 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for intraspecies differences:
- 5
- Justification:
- Default value in line with Section R.8.4.3.1 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for the quality of the whole database:
- 4
- Justification:
- Limited data on the substance itself with regards to developmental and reprotoxicity
- AF for remaining uncertainties:
- 1
- Justification:
- Not applied.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.9 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 400
- Dose descriptor starting point:
- NOAEL
- Value:
- 180 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 360 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
NOAEL(oral) converted to NOAEL(dermal) (180 mg/kg x [50% oral absorption rat/25% dermal absorption humans]) = 360 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- Default value in line with Section R.8.4.3.1 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for differences in duration of exposure:
- 2
- Justification:
- Extrapolation from subchronic study to chronic exposure value in line with Table R.8-5 of Chapter R.8 of Guidance on information requirements and chemical safety assessment 5 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default value for rat in line with Table R.8-3 and Appendix R. 8-2, part 2, example B5 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for other interspecies differences:
- 2.5
- Justification:
- Default value in line with Section R.8.4.3 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for intraspecies differences:
- 5
- Justification:
- Default value in line with Section R.8.4.3.1 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for the quality of the whole database:
- 4
- Justification:
- Limited data on the substance itself with regards to developmental and reprotoxicity
- AF for remaining uncertainties:
- 1
- Justification:
- Not applied.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
(z)-3-hexenyl salicylate does not show any local or acute effects and so DNELs for local and/or acute effects have not been calculated.
The available one generation reproduction study is considered as the most relevant study for the dose descriptor starting point and the NOAEL of 180 mg/kg bw/day (general parental toxicology, parental female reproduction and F1 generation development) from this study has been used as the starting point for the calculation of the systemic DNELs.
DNELs calculated using OECD 422 study results give a higher DNEL than those based on one generation reproduction study - therefore at present it is considered a worst case assessment to use the current DNELs.
DNELs will be re-evaluated based on 90 -day repeat dose toxicity (OECD 408) and pre-natal development toxicity (OECD 414) study results (conducted on substance itself) once available.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.39 mg/m³
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEL
- Value:
- 180 mg/m³
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 78.2 mg/m³
- Explanation for the modification of the dose descriptor starting point:
NOAEL(oral) converted to NOAEC(inhal) (180 mg/kg x [1/1.15 x 50% oral absorption rat/100% inhalation absorption human]) = 78.2 mg/m3
- AF for dose response relationship:
- 1
- Justification:
- Default value in line with Section R.8.4.3.1 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for differences in duration of exposure:
- 2
- Justification:
- Extrapolation from subchronic study to chronic exposure value in line with Table R.8-5 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Not applied as differences in the allometry are assumed to be compensated by differences in the respiration rate.
- AF for other interspecies differences:
- 2.5
- Justification:
- Default value in line with Section R.8.4.3 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for intraspecies differences:
- 10
- Justification:
- Default value in line with Section R.8.4.3.1 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for the quality of the whole database:
- 4
- Justification:
- Limited data on the substance itself with regards to developmental and reprotoxicity
- AF for remaining uncertainties:
- 1
- Justification:
- Not applied
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.45 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 800
- Dose descriptor starting point:
- NOAEL
- Value:
- 180 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 360 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
NOAEL(oral) converted to NOAEL(dermal) (180 mg/kg x [50% oral absorption rat/25% dermal absorption humans]) = 360 mg/kg bw/day
- AF for dose response relationship:
- 1
- Justification:
- Default value in line with Section R.8.4.3.1 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for differences in duration of exposure:
- 2
- Justification:
- Extrapolation from subchronic study to chronic exposure value in line with Table R.8-5 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default value for rat in line with Table R.8-3 and Appendix R. 8-2, part 2, example B5 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for other interspecies differences:
- 2.5
- Justification:
- Default value in line with Section R.8.4.3 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for intraspecies differences:
- 10
- Justification:
- Default value in line with Section R.8.4.3.1 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for the quality of the whole database:
- 4
- Justification:
- Limited data on the substance itself with regards to developmental and reprotoxicity
- AF for remaining uncertainties:
- 1
- Justification:
- Not applied
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.23 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 800
- Dose descriptor starting point:
- NOAEL
- Value:
- 180 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 180 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Same oral absorption in rat and humans
- AF for dose response relationship:
- 1
- Justification:
- Default value in line with Section R.8.4.3.1 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for differences in duration of exposure:
- 2
- Justification:
- Extrapolation from subchronic study to chronic exposure value in line with Table R.8-5 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Default value in line with Table R.8-3 and Appendix R. 8-2, part 2, example B5 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for other interspecies differences:
- 2.5
- Justification:
- Default value in line with Section R.8.4.3 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for intraspecies differences:
- 10
- Justification:
- Default value in line with Section R.8.4.3.1 of Chapter R.8 of Guidance on information requirements and chemical safety assessment
- AF for the quality of the whole database:
- 4
- Justification:
- Limited data on the substance itself with regards to developmental and reprotoxicity
- AF for remaining uncertainties:
- 1
- Justification:
- Not applied
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
(z)-3-hexenyl salicylate does not show any local or acute effects and so DNELs for local and/or acute effects have not been calculated.
The available one generation reproduction study is considered as the most relevant study for the dose descriptor starting point and the NOAEL of 180 mg/kg bw/day (general parental toxicology, parental female reproduction and F1 generation development) from this study has been used as the starting point for the calculation of the systemic DNELs.
DNELs calculated using OECD 422 study results give a higher DNEL than those based on one generation reproduction study - therefore at present it is considered a worst case assessment to use the current DNELs.
DNELs will be re-evaluated based on 90 -day repeat dose toxicity (OECD 408) and pre-natal development toxicity (OECD 414) study results (conducted on substance itself) once available.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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