Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-112-7 | CAS number: 91-97-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to fish:
The 96 -hour LC50 value based on time-weighted-mean measured concentrations was 0.25 mg/L with 95% confidence limits of 0.22 - 0.28 mg/L. The NOEC was determined to be 0.18 mg/L.
Short-term toxicity to aquatic invertebrates
The 48-hour EC50 value based on time-weighted mean measured concentrations was greater than 1.2 mg/L and correspondingly the No Observed Effect Concentration was greater than or equal to 1.2 mg/L.
Toxicity to aquatic algae
The 72-hour EC50 value based on the time-weighted mean measure test concentrations was greater than 1.5 mg/L and correspondingly the No Observed Effect Concentration was greater than or equal to 1.5 mg/L.
Toxicity to microorganism
Based on measured inhibition rates it can be stated that the 3-hour EC20, EC50 and EC80 were higher than 1000 mg/L. The NOEC was determined to be 1000 mg/L.
Additional information
Toxicity to fish:
TODI was tested for acute toxicity to fish according to EU-method C.1 and OECD guideline 203. The 96-hour LC50 based on nominal test concentrations was 1.0 mg/L with 95% confidence limits of 0.90 - 1.1 mg/L. The No Observed Effect Concentration was 0.72 mg/L.
TODI as such is hardly soluble in water (See IUCLID section 4.6., water solubility), therefore Dimethylformamide was used as auxiliary solvent / dispersant in the acute toxicity fish test. Moreover, TODI showed to be highly unstable in aqueous media, with hydrolysis occurring virtually instantaneously on contact with water and the degradation product was found to be insoluble in organic and aqueous solvents. (See IUCLID section 6.1.1, short-term toxicity to fish). That means that (1.) the acute toxicity test in fish represents the worst case as the solubility in water was increased by an auxiliary solvent and (2.) a chronic exposure to the TODI, respectively to its degradation product is negligible due to the insolubility of both if no auxiliary solvent is used. Since (2.) represents the real and not the worst case scenario, a long-term fish study is not justified.
Toxicity to daphnia:
The acute toxicity of the test material TODI to the freshwater invertebrate Daphnia magna has been investigated and based on the nominal concentration gave a 48-hour EC50 of greater than 4.0 mg/L. Correspondingly the No Observed Effect Concentration was greater than or equal to 4.0 mg/L. The 48-hour EC50 value based on time-weighted mean measured concentrations was greater than 1.2 mg/L and correspondingly the No Observed Effect Concentration was greater than or equal to 1.2 mg/L.
TODI as such is hardly soluble in water (See IUCLID section 4.6., water solubility), therefore Dimethylformamide was used as auxiliary solvent / dispersant in the acute toxicity fish test. Moreover, TODI showed to be highly unstable in aqueous media, with hydrolysis occurring virtually instantaneously on contact with water and the degradation product was found to be insoluble in organic and aqueous solvents (see IUCLID section 6.1.3, short-term toxicity to aquatic invertebrate). That means that (1.) the acute toxicity test in aquatic invertebrate represents the worst case as the solubility in water was increased by an auxiliary solvent and (2.) a chronic exposure to the TODI, respectively to its degradation product is negligible due to the insolubility of both if no auxiliary solvent is used. Since (2.) represents the real and not the worst case scenario, a long-term study in aquatic invertebrate is not justified.
Toxicity to algae:
TODI was assessed in aquatic toxicity test to algae according EU-method C.3 and OECD guideline 201. The 72-hour EC50 value (nominal) was greater than 4.0 mg/L and correspondingly the No Observed Effect Concentration was greater than or equal to 4.0 mg/L. The 72-hour EC50 value based on the time-weighted mean measure test concentrations was greater than 1.5 mg/L and correspondingly the No Observed Effect Concentration was greater than or equal to 1.5 mg/L.
Toxicity to aquatic microorganisms:
TODI was assessed in an activated sludge respiration inhibition test, according to the EU-method C. 11 and OECD guideline 209. Based on measured inhibition rates it can be stated that the 3-hour EC20, EC50 and EC80 were higher than 1000 mg/L. The NOEC was determined to be 1000 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)