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Diss Factsheets
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EC number: 231-743-0 | CAS number: 7718-54-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Value used for CSA:
Skin irritation / corrosion: irritating
Eye irritation: not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
There is some human data for skin irritancy of nickel chloride, but no skin or eye irritation data from animal studies on nickel chloride have been found. Human data for nickel chloride shows skin irritation, and classification is considered relevant. Skin irritation is also seen with nickel sulphate in similar studies.Nickel chloride is classified as Skin Irrit. 2: H315 in the 1st ATP to the CLP Regulation with a specific concentration limit of 20%.
Data on eye irritation is available for nickel sulphate. There is no reason to believe that the eye irritating potential of nickel chloride will exceed that of nickel sulphate. Nickel chloride is not classified for eye irritation under CLP.
Regarding respiratory irritation the available data on nickel chloride do not allow a conclusion for this endpoint.
The following information is taken into account for any hazard / risk assessment:
There are some human data for skin irritancy of nickel chloride, but no skin or eye irritation data from animalstudies on nickel chloride have been found. Human data for nickel chloride shows skin irritation, and classification is considered relevant. This is supported by data using read-across from nickel sulphate to set the concentration limit since nickel sulphate has been shown to be irritating to skin in humans at concentrations greater than 20%. A comprehensive summary on this topic is provided in Appendix B3.
Data regarding eye irritation of Ni acetate are read-across from Ni sulphate. Ni sulphate has been demonstrated not to be an eye irritant in experimental animals.
The available data do not allow any conclusion on respiratory irritation.
Value used for CSA:
Skin irritation / corrosion: irritating
Eye irritation: not irritating
Justification for classification or non-classification
Ni chloride is classified as Skin Irrit. 2: H315 in the 1st ATP to the CLP Regulation with a specific concentration limit of 20%. Ni chloride is not classified for eye irritation based on experimental data in animals with Ni sulphate.A comprehensive summary on this topic is provided in Appendix B3.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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