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Diss Factsheets
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EC number: 236-068-5 | CAS number: 13138-45-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
- A 30 min EC50 of 33 mg Ni/L (Cokgor et al 2007) was the only study carried forward for PNEC-STP derivation.
Key value for chemical safety assessment
Additional information
Toxicity to microorganisms (STP)
Only a few internationally accepted test methods for microorganisms exist, such as the OECD N° 209 (inhibition of respiration of activated sludge) and ISO N° 9509 (inhibition of nitrification). Generally, short-term measurements (in terms of hours) are preferred, generally corresponding with typical retention times in biological STPs. The TGD (EC, 2003) suggests 10 h as a preferable test duration. Furthermore, the information available has to be relevant for the processes that are potentially at risk of disruption, e. g. microbial degradation activity in an STP. To assess risks to these processes, microbial endpoints such as respiration and nitrification inhibition are considered to be the most relevant. Testing using a mixed microbial inoculum is considered more relevant than using single-species inoculum. Thus information reported on individual bacterial species like Microtox (with Vibrio fisherias test organism), Pseudomonas putida, Pseudomonas fluorescens and even Escherichia coli are therefore considered as less relevant than those from mixed inoculum.
It should be noted that, unlike for some other environmental compartments (e.g., water and terrestrial compartment) there are currently no tools available for correcting the PNECmicro-organism for bioavailability. Therefore the effects assessment and risk characterisation for nickel in this compartment are based on non-normalised dissolved nickel concentrations.[e1]
Studies assessing the effects of nickel on ciliated protozoa (preferably T. pyriformis) and respiration/nitrification using bacteria originating from sewage treatment plants were regarded as directly relevant for the derivation of a PNEC STP. The key publication selected for Ni-PNEC STP derivation is Cokgor et al (2007).No other PNEC relevant studies that investigated the effects of Ni on bacterial populations were identified. However, the other studies in the database not deemed directly relevant, supported the relevancy and the conservative nature of an EC50of 33 mg/L.
[e1]Remove and insert into STP PNEC derivation section
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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