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Diss Factsheets
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EC number: 203-906-6 | CAS number: 111-77-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
A number of bacterial reverse mutation (Ames) assays have been performed on 2 -(2 -methoxyethoxy)ethanol covering the S. typhimurium strains TA97, TA98, TA100, TA1535, TA1537 and the E. coli strain WP2uvrA. All are consistently negative.
There is no in vitro mammalian cell cytogenic or gene mutation data available for this substance. However, an analogue read across justification is attached to this dossier to justify using read across data from similar source substances.
In an in vitro forward gene mutation assay at the HGPRT locus of CHO cells, 2 -(2 -butoxyethoxy)ethanol did not elicit a positive response when tested up to the maximum recommended dose of 5000ul/ml with and without S9 metabolic activation. In an in vitro cytogenicity assay using Chinese Hamster Ovary cells with and without metabolic activation, there was no evidence of cytogenic properties when tested at doses of 2 -(2 -butoxyethoxyethanol) up to those that cause cytotoxicity. In a GLP and guideline (TSCA) CHO / HGPRT gene mutation assay, TEGME tested at concentrations up to 5000 ug/ml did not produce evidence of mutation with or without exogenous metabolic activation by rat liver S-9.
In a GLP and guideline study, EGnPE tested at concentrations up to 1mg/mL in a mammalian cell gene mutation assay using mouse lymphoma L5178Y cells did not produce evidence of a toxicologically significant increases in the mutant frequency at the TK +/- locus with or without exogenous metabolic activation by rat liver S-9.
In an in vitro cytogenicity assay using 2 -(2 -butoxyethoxy)ethanol in Chinese Hamster Ovary cells with and without metabolic activation, there was no evidence of cytogenic properties when tested at doses up to those that cause cytotoxicity. Brake Fluid DOT 4, a mixture primarily of borated and unborated triethylene glycol methyl ether, was tested for potential to cause chromosomal aberrations (CA) in cultured Chinese hamster ovary cells (CHO), at concentrations up to 5000 micrograms/mL, in the presence or absence of S9 mix. No treatment-related increase in incidence of chromosomal aberrations was observed with the test substance. Positive controls benzo(a)pyrene, and methylmethanesulfonate showed significantly increased CA formation. In a guideline mammalian cell chromosome abberation study using human lymphocytes, EGnPE did not induce statistically significant increases in the frequency of cells with chromosome aberrations in either the absence or presence of a liver enzyme metabolizing system in either of two experiments. The test item was considered non-clastogenic to human lymphocytes in vitro. Because of the structural similarity between the source substances and DEGME, particularly with respect to function groups and their surrounding atomic environment, these results can be reliably extrapolated from the former to the latter. A detailed justification for read across and interpolation between these substances is included in an attachment to chapter 13 included with the lead registrants dossier.
Short description of key information:
Tests with registration substance
- Ames: negative (2 studies)
Tests on a surrogate substances:
- Mouse lymphoma test: negative
- Cytogenicity assay (CHO): negative
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
It can be concluded from the data available that mutagenicity and genotoxicity are not likely to be manifest by 2-(2-methoxyethoxy)ethanol and therefore classification for this end point is not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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