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Diss Factsheets
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EC number: 204-658-1 | CAS number: 123-86-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well described study
- Qualifier:
- according to guideline
- Guideline:
- other: "the moving average method" (Weil, 1983)
- Principles of method if other than guideline:
- Female Sprague-Dawley rats (200-300 grams) received 4.0, 8.0, 11.3, or 16.0 ml/kg (3520, 7040, 9944, and 14080 mg/kg) of n-butyl acetate by gavage. The rats were fasted overnight prior to dosing. The group size at each dose level was 5 animals/group. The LD50 value was calculated by the moving average method (Weil, 1983) after the animals had been observed for 14 days for clinical signs and survival. A gross pathology exam was conducted on animals found dead or at sacrifice.
- GLP compliance:
- no
- Test type:
- other: "the moving average method" (Weil, 1983)
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Route of administration:
- oral: gavage
- Doses:
- Female Sprague-Dawley rats (200-300 grams) received 4.0, 8.0, 11.3, or 16.0 ml/kg (3520, 7040, 9944, and 14080 mg/kg) of n-butyl acetate by gavage.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 10 736 mg/kg bw
- Based on:
- test mat.
- Gross pathology:
- A gross pathology exam was conducted on animals found dead or at sacrifice.
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 is 10736 mg/kg
Reference
Two of five female rats were found dead on the day of dosing and two more on the day following dosing with 16.0 ml/kg. Weight gain in the surviving animal from the 16.0 ml/kg was normal. Clinical signs in the 16.0 ml/kg group included sluggishness at 30 minutes, prostration (2/5 animals) at one hour and moribund appearance (1/5 animals) at 2 hours post-dosing. The two animals were found dead at three hours post-dosing. The surviving animal was normal in appearance on the day following dosing. There were no remarkable gross pathology findings in any animals at this dose level. Two of five female rats were found dead (1/5 on Day 1 and 1/5 on Day 3) following dosing with 11.3 ml/kg. Weight gain in the surviving animals from the 11.3 ml/kg was normal. Clinical signs in the 11.3 ml/kg group included sluggishness (1/5 animals) and prostration (5/5 animals) at 30 minutes post-dosing, and moribund appearance (2/5 animals) at 2 hours (continuing to Day 1). The surviving animals were normal in appearance within one day following dosing. There were no remarkable gross pathology findings in any animals at this dose level. No rats died following dosing with either 4.0 or 8.0 ml/kg. No abnormal clinical signs or changes in weight gain were noted following dosing or upon gross pathology exam at termination in either the 4.0 or 8.0 ml/kg group animals.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 10 736 mg/kg bw
Additional information
oral 001 and oral 002 are the most reliable studies - it is the same study but data for males and females are presented seperately. The endpoint for the study concerning females is chosen as it has the lowest effect level.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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