Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-076-7 | CAS number: 51-03-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- The Safety of Piperonyl Butoxide
- Author:
- Breathnach, R.
- Year:
- 1 998
- Bibliographic source:
- Jones, G.G., Piperonyl Butoxide the Insecticide Synergist, Academic Press, San Diego
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 413 (Subchronic Inhalation Toxicity: 90-Day Study)
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Piperonyl Butoxide
- IUPAC Name:
- Piperonyl Butoxide
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles River CD
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Remarks on MMAD:
- MMAD / GSD: 97% of particles were 10 µm or less
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 6 hours per day, 5 days per week, 13 weeks
- Frequency of treatment:
- once on five days per week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
15, 74, 155, 512 mg/m³
Basis:
analytical conc.
- No. of animals per sex per dose:
- 15
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 155 mg/m³ air
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: systemic effecst (Hepatotoxicit at higher dose level local effecst (Larynx)
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
There were no effects on body-weight gain, food consumption or ocular effects and all animals survived to the end of treatment.
A dose-related increase in nasal discharge, dried material on the facial area and extremities, and anogenital staining in animals at 155 and 512 mg/m³.
At the high dose increases in the absolute and relative weights of the livers and kidneys were seen. Vesiculation and vacuolation of the hepatocellular cytoplasm was seen in almost all treated animals but tended to be more pronounced in those at the highest level.
Squamous or squamoid metaplasia of the pseudostratified columnarepithelium of the larynx was seen in several exposed animals and one control female, the severity being greater in animals at the high dose. Similar metaplastic changes were seen in the columnar epithelium lining the ventral diverticulum in several animals at 512 mg/m3and in one female at 15 mg/m3. Hyperplasia and hyperkeratosis of the squamous epithelium normally found in the larynx were seen in a small number of animals at 512 mg/m3. Laryngeal mucosal inflammation was seen in all treated animals and was slightly more severe in animals at the highest dose. All of the changes were considered to be localized responses indicative of irritation rather than systemic toxicity.
No systemic toxicity was seen at 155 mg/m3; effects on the liver and kidney were seen at 512 mg/m3.
Applicant's summary and conclusion
- Conclusions:
- No systemic toxicity was seen at 155 mg/m³; effects on the liver and kidney were seen at 512 mg/m³.
Local effects were most pronounced at the highest dose level.
The overall NOAEC was 155 mg/m³ for local and systemic effects. - Executive summary:
Groups of 15 Charles River CD rats of each sex were exposed by inhalation for 6 h per day, five days per week, for 13 weeks to piperonyl butoxide (purity, 90.78%) at mean analytical concentrations of 15, 74, 155, or 512 mg/m³. There were no effects on body-weight gain, food consumption or ocular effects and all animals survived to the end of treatment. A dose-relate increase in nasal discharge, dried material on the facial area and extremities, and anogenital staining in animalsat 155 and 512 mg/m³.
At the high dose increases in the absolute and relative weights of the livers and kidneys were seen.Local effects larynx was observed and most severe at the highest dose level.
The overall NOAEC was 155 mg/m³ for local and systemic effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.