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Diss Factsheets
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EC number: 205-031-5 | CAS number: 131-57-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June-July 1969
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: meets basic scientific principles, well documented information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-hydroxy-4-methoxybenzophenone
- IUPAC Name:
- 2-hydroxy-4-methoxybenzophenone
- Reference substance name:
- Oxybenzone
- EC Number:
- 205-031-5
- EC Name:
- Oxybenzone
- Cas Number:
- 131-57-7
- Molecular formula:
- C14H12O3
- IUPAC Name:
- 2-benzoyl-5-methoxyphenol
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: commercial breeder (SPF)
- Weight at study initiation: 112.5 (104-121) g
- Fasting period before study: no
- Housing: single in MACROLON cages Type III
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous suspension in 0.5 % carboxymethylcellulose
- Details on oral exposure:
- Given orally by way of an esophageal tube, in the form of a 16 - 32% aqueous suspension in 0.5% carboxymethyl cellulose.
- Doses:
- 1600, 3200, 6400, 12800 mg/kg
- No. of animals per sex per dose:
- ten (5 males, 5 females)
Total number of animals: forty (20 males, 20 females) - Control animals:
- not specified
- Details on study design:
- 40 rats (20 females, 20 males) were orally exposed at dose levels of 1600, 3200, 6400, 12800 mg/kg. Observations were recorded after 1, 7, 14 days observation period.
- Statistics:
- standard statistical methods
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 12 800 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All the animals survived the 14-day observation period.
- Clinical signs:
- other: Most of the test animals exhibited sluggishness and/or slept for up to one hour following the application of the substance .Thereafter, no further changes were noted in the general condition and behavior of the animals.
- Gross pathology:
- One animal presented atelectasis of one of the lung lobes. All the other animals were unremarkable.
- Other findings:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In conclusion, LD50 after 1, 7 and 14 days of observation was in excess of 12,800 mg/kg in rats by orally.
- Executive summary:
Total 40 Wistar rats were exposed test article by orally at dose levels of 1600, 3200, 6400, 12800 mg/kg to assess the potential of acute toxicity. All the animals survived the 14-day observation period. There were no abnormal observations in the body weight during the test. Most of the test animals exhibited sluggishness and/or slept for up to one hour following the application of the substance .And no further changes were noted in the general condition and behavior of the animals.One animal presented atelectasis of one of the lung lobes. All the other animals were unremarkable.
Based on the results, it can be concluded that LD50 of test article was greater than 12800 mg/kg after 1, 7 and 14 days of observation.
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