Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 282-208-3 | CAS number: 84144-87-6 Flue dust and ash containing vanadium resulting from the combustion of vanadium-bearing fuel oil.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03.05.2010-25.05.2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- no
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Ashes (residues), vanadium-contg.
- EC Number:
- 282-208-3
- EC Name:
- Ashes (residues), vanadium-contg.
- Cas Number:
- 84144-87-6
- Molecular formula:
- Not available
- Reference substance name:
- vanadium concentrate
- IUPAC Name:
- vanadium concentrate
- Details on test material:
- - Name of test material (as cited in study report): vanadium concentrate
- Lot/batch No.: 14-45810
- Preperation date: 07/2009
- Expiry date: 30. Sept. 2011
Constituent 1
Constituent 2
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Details on mammalian cell type (if applicable):
- no data
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- E. coli WP2 uvr A pKM 101
- Details on mammalian cell type (if applicable):
- no data
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- 2-Aminoantracene, Benzo(a)pyrene
- Test concentrations with justification for top dose:
- Sample was analyzed at these concentrations: 5, 1.6, 0.5, 0.16, 0.05 mg/plate
- Vehicle / solvent:
- Water: Recently distilled, not demineralised and sterilized in autoclave Water without bacteria toxic or inhibitory substances.
Controls
- Untreated negative controls:
- yes
- Remarks:
- 100 µL of distilled sterile water
- Negative solvent / vehicle controls:
- yes
- Remarks:
- water
- True negative controls:
- no
- Positive controls:
- yes
- Remarks:
- 100 µL of the positive controls solution, specific for each strain
- Positive control substance:
- other: Sodium azide (CAS: 26628-22-8), 2-Nitrofluorene (CAS: 607-57-8), 9-Aminoacridine hydrochloride hydrate (CAS: 52417-22-8), N-Nitroquinoline-1-oxide (CAS: 56-57-5), 2-AminoAntracene (CAS: 613-13-8), Benzo(a)pyrene (CAS: 8165 BP)
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation)
DURATION
- Preincubation period: none
- Exposure duration: 72 h at 37 °C on a Vogel Bonner plate after adding 100 µL of working solution (and S9 mix for the metabolic activation test)
SELECTION AGENT (mutation assays): UV for uvrA/B mutation; crystal violet for rfa mutation and ampicillin for R factor plasmid
NUMBER OF REPLICATIONS:
without metabolic activation system: test was carried out in triplicates for negative control, positive control and test substance
with metabolic activation system: test was carried out in triplicate for the negative control and in duplicates for the positive control and test substance - Evaluation criteria:
- CRITERIA FOR A POSITIVE RESPONSE IN TESTER STRAINS
Tester Strains TA98, TA 100 and WP2uvrA
The test substance is considered positive when, in at least one of these tester strains, it produces at least a 2-fold rise of the increase value over the increase value in the appropriate vehicle control (see tables 2-6). This rise in the increase value must be accompanied by a positive Dunnet’s test (alpha = 0.05 1-sided) and a dose response when the concentrations of the test substance is increased.
Tester Strains TA1535, TA1537
The test substance is considered positive when, in at least one of these tester strains, it produces at least a 3-fold rise of the increase value over the increase value in the appropriate vehicle control (see tables 2-6). This rise in the increase value must be accompanied by a positive Dunnet’s test (alpha = 0.05 1-sided) and a dose response when the concentrations of the test substance is increased.
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Species / strain:
- E. coli WP2 uvr A pKM 101
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- not valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
In this study the test substance does not induce significative point mutations. - Executive summary:
In a reverse gene mutation assay in bacteria, four strains of S. typhimurium (TA98, TA100, TA1535, TA1537) and one strain of E. coli (WP2 uvrA pKM101) were exposed to Vanadium concentrate at concentrations of 5, 1.6, 0.5, 0.16, 0.05 mg/plate in the presence and absence of mammalian metabolic activation.
Vanadium concentrate was tested up to the limit concentration (5 mg/plate). The positive controls induced the appropriate responses in the corresponding strains. There was no evidence or a concentration related positive response of induced mutant colonies over background.
This study is classified as acceptable. This study satisfies the requirement of OECD 471 for in vitro mutagenicity (bacterial reverse gene mutation).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.