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EC number: 231-106-7 | CAS number: 7439-97-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: Human data
- Adequacy of study:
- weight of evidence
- Reliability:
- other: Relevant
- Rationale for reliability incl. deficiencies:
- other: Relevant
Data source
Reference
- Reference Type:
- publication
- Title:
- Mercury allergy in a contact dermatitis clinic in Northern Ireland
- Author:
- Handley, J. et al.
- Year:
- 1 993
- Bibliographic source:
- Contact Dermatitis 29, 258-261.
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- survey
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: International Contact Dermatitis Research Group (ICDRG) scale (European standard series (Trolab)
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Mercury
- EC Number:
- 231-106-7
- EC Name:
- Mercury
- Cas Number:
- 7439-97-6
- Molecular formula:
- Hg
- IUPAC Name:
- mercury
- Reference substance name:
- Aminomercury chloride
- EC Number:
- 233-335-8
- EC Name:
- Aminomercury chloride
- Cas Number:
- 10124-48-8
- IUPAC Name:
- aminomercury(1+) chloride
- Reference substance name:
- Mercury dichloride
- EC Number:
- 231-299-8
- EC Name:
- Mercury dichloride
- Cas Number:
- 7487-94-7
- IUPAC Name:
- mercury dichloride
- Details on test material:
- - Name of test material (as cited in study report): Mercury metal (1 % pet.)
- Molecular formula (if other than submission substance): Hg
- Name of test material (as cited in study report): Ammoniated mercury chloride (1% pet.)
- Molecular formula (if other than submission substance): HgNH2Cl
- Name of test material (as cited in study report): Mercuric chloride (0.1 % aq.) (Chemotechnique Diagnostics, Batch number 91174A)
- Molecular formula (if other than submission substance): HgCl2
No further information on the test material was stated.
Constituent 1
Constituent 2
Constituent 3
Method
- Type of population:
- general
- Ethical approval:
- not applicable
- Remarks:
- This is not a volunteer study.
- Subjects:
- - Number of subjects: 441 consecutive patients were patch tested
- Sex: 294 female / 147 males
- Age: Age range of 23 to 55 years (This is only the age range of patients that reacted positive to mercury ocompounds during the patch test.)
- Demographic information: different occupations were stated for the patients, which reacted positive to mercury compounds during the patch test: hairdresser, office housewife, radiographer, spinner, kitchen, stitcher, nurse, and cleaner. - Clinical history:
- Of the 14 patients, which reacted positive to the mercury compounds tested during the patch test, 2 of these patients gave a history of clinical symptoms related to mercruy allergy. One patient developed swelling, itching and redness of the cheek following insertion of amalgam fillings on 3 separate occasions. Another patient developed stomatitis more than a year after insertion of amalgam fillings. The stomatitis resolved after the removal of the fillings. The patient also subsequently developed allergic contact dermatitis on separate occasions from contact lens solutions, shampoos, cosmetics and paints, all of which contained mercury preservatives. All 14 patients had been vaccinated in childhood with vaccines containing thimerosal and had had dental amalgam restorations. No other sources of mercury sensitization were identified.
- Controls:
- no data
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
During a 12-month period, all patients attending a clinic with suspected contact dermatitis were routninely patch tested to the European standard series (trolab) and mercury metal (HG) (1 % pet.), ammoniated mercury chloride (HgNH2Cl (1 % pet.) (both Trolab), and mercuric chloride (HgCl2) (=.1 % aq.) (Chemotechnique Diagnostics, Batch number 91174A). Patch test allergens were applied in Finn Chambers mounted on Scanpor tape to the upper back, removed at 2 days and read at 3 days. Grading was according to the International Contact Dermatitis Research Group (ICDRG) scale. Any patient who showed a + or greater response to any of the mercury compounds answered a standard questionnaire. Patients were specifically asked about the following: (a) childhood vaccinations, especially for diphteria and tetanus, and any adverse reactions; (b) insertion of amalgam fillings and any related adverse reactions; (c) tattoos, especially regarding reactions to red colouring; (d) direct contact with mercury metal, e.g., from a broken thermometer; (e) any adverse reactions to antiseptic preparations, cosmetics, shampoos, skin bleaching creams, paints, herbicides or fungicides.
Results and discussion
- Results of examinations:
- 14 patients (3.2%) showed a + or greater response to 1 or more of the 3 mercury compounds. 7 patients to all 3 compounds, 4 to both ammoniated mercury chloride and mercury metal, 2 to mercury metal alone and 1 to ammoniated mercury chloride alone.
No patient reacted to mercuric chloride alone.
12 of these mercury-sensitive patients were female and 6 also reacted to nickel sulphate.
Applicant's summary and conclusion
- Conclusions:
- 14 patients (3.2%) showed a + or greater response to 1 or more of the 3 mercury compounds. 7 patients to all 3, 4 to both ammoniated mercury and mercury metal, 2 to mercury metal alone and 1 to ammoniated mercury alone. No patient reacted to mercuric chloride alone. 12 of these mercury-sensitive patients were female and 6 also reacted to nickel sulphate.
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