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Diss Factsheets
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EC number: 807-421-6 | CAS number: 260359-57-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
Reference
- Name:
- Unnamed
- Test material form:
- liquid
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Purity : 96.7 %
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Two groups of rats (5 males and 5 females) were used for the study.
TEST ANIMALS
- Source: Jai Research Foundation
- Age at study initiation: 8 to 9 weeks
- Weight at study initiation: male between 258 and 196 g; female between 184 and 162 g kg
- Housing: the rats are divided in two groups
- Diet:. ad libitum
- Water : ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 to 23°C
- Humidity (%): 64-66%
- Air changes (per hr): min 15/h
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- other: 80% polyethylen glycol in distilled water
- Remarks:
- The test item is pratically not soluble in distilled water.
- Duration of exposure:
- 4 h
- Concentrations:
- Rat from Group I were exposed to 80% polyethylene glycol in distilled water and served as the control group. Rats from Group II were exposed to the maximum achievable breathing zone concentration (2.865 mg/l air) of test item in 80% polyethylene glycol at the calculated nominal concentration of 23.111 mg/l of auer in the inhalation chamber.
- No. of animals per sex per dose:
- Two groups of rats (5 males and 5 females) were used for the study.
- Control animals:
- yes
- Details on study design:
- Observation period: 14 days
All rats were observed for any signs and mortality at hourly intervals during the 4 h exposure period and at 1 h after the exposure on the day of exposure. The surviving rats were observed twice a day for morbidity and mortality for a period of 14 day following exposure. The clinical signs were recorded once a day.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2 865 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortality occurred at the maximum achievable breathing zone concentration.
- Clinical signs:
- other: nasal discharge, nasal irritation, lethargy
- Body weight:
- No effect.
- Gross pathology:
- No lesion of toxicological sigificance were observed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Since no mortality occurred at the maximum achievable breathing zone concentration of d-trans Allethrine 75/25 in 80% of polyethylene glycol at the calculated nominal concentration of 23.111 mg/l of aier, the substance was not classified for this endpoint.
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