Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-696-2 | CAS number: 13927-77-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8 Jul 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1981
- GLP compliance:
- no
- Specific details on test material used for the study:
- - Name of test item (as cited in study report): Nickeldibutyldithiocarbamate (NiDBC)
- Source: Akzo Chemicals Dordrecht
- Purity: 97% - Analytical monitoring:
- not specified
- Vehicle:
- yes
- Remarks:
- acetone
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
A stock solution in acetone was made, from which a second stock solution in dilution water was prepared. - Test organisms (species):
- Poecilia reticulata
- Details on test organisms:
- - Common name: Guppy
- Source: Inhouse (Akzo Research Laboratories Arnhem, dpt. CRL)
- Length at study initiation: ≤ 2 cm - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 21 - 25 °C
- Details on test conditions:
- TEST SYSTEM
The test organisms were bred in the Akzo Research Laboratories Arnhem, dpt. CRL. The fish were kept and tested at 23 ± 2 °C. Young fish, ≤ 2 cm, were used in the test.Test containers were 2 L glass aquaria filled with 1 L test medium. The test medium was refreshed after 48 hours. Observations on survival were made daily. Measurements of oxygen concentration, pH and temperature were carried out to confirm that the test conditions were normal. The loading in the glass vessels was approximately 0.6 g biomass/L. The number of organisms per vessel was 10.
TEST MEDIUM
The dilution water was a synthetic medium, Dutch Standard Water, containing 100 mg NaHCO3/L, 20 mg KHCO3/L, 200 mg CaCl2.2H2O/L and 180 mg MgSO4.7H2O/L. The medium was aerated before use. The medium was renewed after two or three days. - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 16 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: saturated concentration
- Reported statistics and error estimates:
- The 96-h LC50 was determined with a programme of RIZA (Griffioen, not published) based on the LC50 model of Kooijman (1981). This model includes the data from each observation time in its calculation of the LC50. Therefore it enables calculation of 96-h LC50 values even in cases where only one or no concentration with partial mortality occurred. The model also corrects for control mortality.
- Validity criteria fulfilled:
- not specified
Reference
Description of key information
The 96-h LC50 value is >16 mg/L in guppies (Poecilia reticulata).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 16 mg/L
Additional information
The short-term toxicity to freshwater fish was determined in a non-GLP study similar to OECD TG 203. In this study, groups of 10 guppies (Poecilia reticulata) were exposed for 96 hours to at least a saturated concentration of 16 mg/L. The study was semi-static with a 48-hour renewal of test media. No analytical confirmation was performed. Observations on survival were made daily. Measurements of oxygen concentration, pH and temperature were carried out to confirm that the test conditions were normal. The loading in the glass vessels was approximately 0.6 g biomass/L. After 96 hours, the 96-hour LC50 was determined to be >16 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.