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EC number: 218-080-2 | CAS number: 2050-08-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study in accordance with EU Method B.1.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1981
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Pentyl salicylate
- EC Number:
- 218-080-2
- EC Name:
- Pentyl salicylate
- Cas Number:
- 2050-08-0
- Molecular formula:
- C12H16O3
- IUPAC Name:
- pentyl 2-hydroxybenzoate
- Reference substance name:
- 2-methylbutyl salicylate
- EC Number:
- 256-972-3
- EC Name:
- 2-methylbutyl salicylate
- Cas Number:
- 51115-63-0
- Molecular formula:
- C12H16O3
- IUPAC Name:
- 2-methylbutyl 2-hydroxybenzoate
- Test material form:
- liquid
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): PENTYL-2- HYDROXYBENZOAT
- Structural formula attached as image file (if other than submission substance): see Fig.
- Physical state: Liquid
- Storage condition of test material: Room temperature
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Range finder: 5000mg/kg bw, 2000mg/kg bw, 200 mg/kg and 20mg/kg bw
Main study: 2000mg/kg bw - No. of animals per sex per dose:
- Ranger finder: 1 male and 1 female per dose level
Main study: 10 males and 10 females per dose level. - Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral median lethal dose (LD50) of the test material in Sprague Dawley strain rat was considered to be approximately 2000mg/kg body weight.
- Executive summary:
A study was performed to determine the acute oral median lethal dose (LD50) of the test material, administered as a solution in arachis oil B.P in the Sprague-Sawley strain rat. The method used followed that described in the OECD Guideline for Testing of Chemicals (1981) No, 401 "Acute Oral Toxicity".
Following a range finding study, a group of ten fasted animals (five males and five females) was given a single oral dose of test material preparation at a dose level of 2000mg/kg bw.
Five animals (three males and two females) were found dead one to three days after treatment. Signs of toxicity noted were hunched posture, lethargy and pilo-erection. Additional or isolated signs of toxicity noted were ptosis, red/brown staining around the snout and eyes, ataxia, dehydration, tiptoe gait and decreased respiratory rate. Surviving animals appeared normal four days after treatment.
Incidents of reduced gain in bodyweight and body loss were noted during the study period.
Abnormalities noted at necropsy of animals that died during the study were haemorrhagic or abnormally red lungs, dark or pale liver, pale spleen, haemorrhage of the glandular gastric epithelium, sloughing of the non-glandular gastric epithelium and haemorrhage of the small intestine.
Abnormalities noted at necropsy of animals that were killed at the end of the study included included pale liver, adhesion of the stomach to the liver and multiple white foci approximaely 2mm x 2mm over 75% of the non-glandular epithelium of the stomach.
No abnormalities were noted at necropsy of the three remaining animals that were killed at the end of the study.
The acute oral median lethal dose (LD50) of the test material, HR 90/660541, to the Sprague Dawley strain rat was considered to be approximately 2000mg/kg bw.
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