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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 213-485-0 | CAS number: 957-68-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- other: Compilation and interpretation of available data.
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Compilation and interpretation of available data.
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to other study
- Objective of study:
- absorption
- distribution
- excretion
- metabolism
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Section R.7.12.2.1 of the 'Guidance on information requirements and chemical safety assessment'
- Version / remarks:
- 2017
- Deviations:
- not specified
- Principles of method if other than guideline:
- Compilation and interpretation of available data.
- GLP compliance:
- no
- Radiolabelling:
- no
- Details on absorption:
- No relevant systemic toxic effects were noted in the acute oral and the acute inhalation toxicity studies.
Guidance for an oral absorption:
Based on the Section R.7.12.2.1 of the 'Guidance on information requirements and chemical safety assessment' some of the relevant physical-chemical properties for an oral absorption are:
- Ionic groups in the molecule are present and do not favour an absorption. The low pH of stomach may favour the absorption of the acidic molecule, but not of the contained amino-group.
- Molecular weights below 500 are favourable for absorption. 7-ACA has a molecular weight of 272.
- The water solubility of 7-ACA is low: 611 mg/L at 20 °C.
- The low n-octanol/water partition coefficient (log Pow <-3.4) for 7-ACA does not enable an extensive absorption by passive diffusion.
These data point to a low to moderate oral absorption - in agreement with no observed toxic effects in the available acute oral toxicity study.
Guidance for an inhalation absorption:
An acute inhalation toxicity study in rats with a MMAD of 3.65 µm did not show systemic toxic effects at the limit concentration of 5.24 mg/L, therefore no indication of an absorption was obtained. The relevant parameters for absorption at inhalation exposure are not very different to those for oral absorption, as described in the Section R.7.12.2.1 of the 'Guidance on information requirements and chemical safety assessment'.
Guidance for a dermal absorption:
For dermal absorption an even lesser absorption is predicted compared to the oral route, based on the following criteria:
- Molecular Weight: The range between 100 and 500 favours dermal uptake.
- n-octanol/water partition coefficient: For substances with log P values <0, poor lipophilicity will limit penetration into the stratum corneum and hence dermal absorption. Values <–1 suggest that a substance is not likely to be sufficiently lipophilic to cross the stratum corneum, therefore dermal absorption is likely to be low.
- Water Solubility: The substance must be sufficiently soluble in water to partition from the stratum corneum into the epidermis - Details on distribution in tissues:
- Distribution:
No indication from the available studies was obtained on the possible distribution of the substance in the body.
Bioaccumulation:
No relevant accumulation is expected, based on the low log Pow. - Details on excretion:
- Excretion:
No relevant data are available, which provide evidence on the route of excretion. - Details on metabolites:
- Metabolism:
No relevant differences occurred in the mutagenicity studies with and without the addition of a metabolising system. Therefore no indication of the importance of the metabolism of the test substance was obtained from these studies. - Conclusions:
- The toxicokinetic behaviour of the test item was estimated from available data.
No evidence of an oral absorption was obtained from the available acute toxicity tests. A low oral absorption is also predicted from the phys.-chem. properties of the substance.
No evidence of an inhalation absorption was obtained from the available acute toxicity test. The dermal absorption is predicted to be lower compared to the oral route.
No evidence of a distribution or of the way of excretion was obtained.
No evidence of metabolisation was obtained from the mutagenicity tests with and without metabolising systems.
No bioaccumulation is expected, based on the low log Pow. - Executive summary:
The toxicokinetic behaviour of the test item was estimated from available data.
No evidence of an oral absorption was obtained from the available acute toxicity tests. A low oral absorption is also predicted from the phys.-chem. properties of the substance.
No evidence of an inhalation absorption was obtained from the available acute toxicity test. The dermal absorption is predicted to be lower compared to the oral route.
No evidence of a distribution or of the way of excretion was obtained.
No evidence of metabolisation was obtained from the mutagenicity tests with and without metabolising systems.
No bioaccumulation is expected, based on the low log Pow.
Reference
Description of key information
A compilation and interpretation of available data is presented.
No evidence of an oral absorption was obtained from the available acute toxicity tests. A low oral absorption is also predicted from the phys.-chem. properties of the substance.
No evidence of an inhalation absorption was obtained from the available acute toxicity test. The dermal absorption is predicted to be lower compared to the oral route.
No evidence of a distribution or of the way of excretion was obtained.
No evidence of metabolisation was obtained from the mutagenicity tests with and without metabolising systems.
No bioaccumulation is expected, based on the low log Pow.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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