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Diss Factsheets
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EC number: 214-275-1 | CAS number: 1119-34-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of Selected Amino Acids on Ethanol Toxicity in Rats
- Author:
- Breglia R J
- Year:
- 1 973
- Bibliographic source:
- Journal of Pharmaceutical Sciences, vol. 62(1), pp. 49-55
Materials and methods
- Principles of method if other than guideline:
- - Principle of test:
Determination of acute toxicity by Seventy-Two-Hour LD50 calculation. The number dead at 72 hr. was counted and analyzed by the method of Litchfield and Wilcoxon (J. T. Litchfield, Jr., and F. Wilcoxon, J. Pharmacol. Exp Ther., 96, 99(1949))
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- (+)-L-arginine hydrochloride
- EC Number:
- 214-275-1
- EC Name:
- (+)-L-arginine hydrochloride
- Cas Number:
- 1119-34-2
- Molecular formula:
- C6H14N4O2.ClH
- IUPAC Name:
- L-arginine hydrochloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 2 months
- Weight at study initiation: 125-150 g
- Fasting period before study: 24 h
- Housing: no data
- Diet (e.g. ad libitum): Ad libitum.
- Water (e.g. ad libitum): Ad libitum.
- Acclimation period: 1 week
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- (distilled water)
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 6 ml
- Concentration in vehicle: 10 and 20 % (w/v)
- Justification for choice of vehicle: Destilled water has no impact on its own
MAXIMUM DOSE VOLUME APPLIED: 6 ml - Doses:
- 10 and 20 % (w/v) in vehicle
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 72 hours
- Frequency of observations and weighing: mortality at 72 h.
- Other examinations performed: ataxia and sleeping time.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 12 400 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 12.40 ± 0.61 (calculated by the method of Litchfield and Wilcoxon)
- Mortality:
- Not specified.
- Clinical signs:
- Some signs of toxicity did appear such as ataxia, dyspnea, decreased muscle tonus, and loss of righting reflex. Toxicity signs were first observed 11 g/kg bw.
- Body weight:
- Not specified.
- Gross pathology:
- not specified.
Applicant's summary and conclusion
- Interpretation of results:
- other: No category (CLP Regulation EC no. 1272/2008)
- Conclusions:
- LD50 of L-argine-HCl was determined to be 12400 mg/kg b.w. in a toxicity study with rats.
- Executive summary:
The acute oral toxicity of L-argine-HCl was investigated with Sprague-Dawley rats. Test item was administered at two dose levels of 10 and 20% (w/v) in distilled water (five males and five females per group). After 72 hours, neurological parameters like ataxia or sleeping time were observed and the number of dead was counted and analyzed by the method of Litchfield and Wilcoxon.Some signs of toxicity were reported such as ataxia, dyspnea, decreased muscle tonus, and loss of righting reflex. Toxicity signs were first observed 11 g/kg bw. LD50 of L-argine-HCl was determined to be 12400 mg/kg b.w.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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