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Diss Factsheets
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EC number: 233-271-0 | CAS number: 10102-43-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- The MAK Collection for Occupational Health and Safety
- Author:
- DFG
- Year:
- 2 014
- Bibliographic source:
- Deutsche Forschungsgemeinschaft (2014),The MAK-Collection Part I, MAK Value Documentations, 37p
- Reference Type:
- publication
- Title:
- Experimental studies on nitric oxide
- Author:
- Gustafsson L
- Year:
- 1 993
- Bibliographic source:
- Gustafsson L (1993), Experimental studies on nitric oxide, Scand J Work Environ Health 1993;19(2):44-49
- Reference Type:
- review article or handbook
- Title:
- Oxydes d'azote - fiche toxicologique n°133
- Author:
- INRS
- Year:
- 2 006
- Bibliographic source:
- INRS (2006), Oxydes d'azote - fiche toxicologique n°133, 9p
- Reference Type:
- other: SDS
- Title:
- Unnamed
- Year:
- 2 015
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 017
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Nitrogen monoxide
- EC Number:
- 233-271-0
- EC Name:
- Nitrogen monoxide
- Cas Number:
- 10102-43-9
- Molecular formula:
- NO
- IUPAC Name:
- oxidoamine
Constituent 1
- Specific details on test material used for the study:
- No information on test material in the various sources
Test animals
- Species:
- other: rats and mice
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 112.8 ppm
- Exp. duration:
- 1 h
- Remarks on result:
- other: source: INRS ; species: rats
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 115 ppm
- Exp. duration:
- 1 h
- Remarks on result:
- other: source: EIGA ; species: rats
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 57.5 ppm
- Exp. duration:
- 4 h
- Remarks on result:
- other: source : SDS ; species: rats
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 320 ppm
- Exp. duration:
- 8 h
- Remarks on result:
- other: source: Gustafsson species: mice
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 128 ppm
- Remarks on result:
- other: source: MAK ; species: rats; exposure duration not mentionned
- Clinical signs:
- other: According to MAK: The formation of MetHb or effects on the central nervous system can be expected after a short-term exposure to NO. These effects have been observed in several studies made on rats and for a wide range of concentrations. According to INR
Any other information on results incl. tables
The various data can be filtered as follows:
- results in mice are ignored (non standard species) as data in rats are available
- results with unknown exposure duration are ignored
Therefore, the most relevant LC50 values in rats are:
- 57.5 ppm /4h
- 112.8-115 ppm /1h
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 based on GHS criteria
- Conclusions:
- According to various consistent sources, the test item has the following LC50 values in rats:
- 57.5 ppm /4h
- 112.8-115 ppm /1h
The classification criteria relate to a 4-hour exposure. According to CLP Regulation, if data for a 4-hour period are not available then extrapolation of the results to 4 hours can be estimated using Haber’s Law : Cnx t = k.
Using a value of n=1 as recommended for extrapolation to longer exposure duration, the two values for 1-hour exposure can be converted into:
- 28.2-28.8 ppm /4h
Overall, three consistent values indicate LC50 values ranging 28.2-57.5 ppm/4h in rats, so based on GHS criteria, the test item is classified as acute inhalation toxicity category 1, H330.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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