Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-989-7 | CAS number: 2592-95-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Experimental data from peer reviewed journal
- Justification for type of information:
- Experimental data from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- Microtox test: The test exposes luminescent organisms in Microtox Acute Reagent to aqueous samples, and measures the increase or decrease in light output by the test organisms.Reagent contains living luminescent bacteria that have been grown under optimal conditions, harvested,and then lyophilized (freeze-dried). The lyophilized bacteria are rehydrated with Reconstitution Solution to provide a ready-to-use suspension of organisms. The test system measures the light output of the luminescent bacteria after they have been challenged by a sample and compares it to the light output of a control (reagent blank) that contains no sample. A difference in light output (between the sample and the control) is attributed to the effect of the sample on the organisms.
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Photobacterium phosphoreum
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 30 min
- Remarks on exposure duration:
- 5-30 min. exposure period
- Hardness:
- No data
- Test temperature:
- 15 degC
- pH:
- range of 5< pH <9
- Dissolved oxygen:
- No data
- Salinity:
- No data
- Conductivity:
- No data
- Nominal and measured concentrations:
- No data
- Details on test conditions:
- No data
- Reference substance (positive control):
- yes
- Key result
- Duration:
- 30 min
- Dose descriptor:
- EC50
- Effect conc.:
- 86.4 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: viability and sensitivity
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The median effective concentration (EC50) for the test substance, in microorganism (Photobacterium phosphoreum) in a 5-30 minute study on the basis of viability and sensitivity effect was observed to be 86.4 mg/L.
- Executive summary:
The median effective concentration (EC50) for the test substance, in microorganism (Photobacterium phosphoreum) in a 5-30 minute study on the basis of viability and sensitivity effect was observed to be 86.4 mg/L.
Reference
Description of key information
Toxicity to microorganism:
Data available for the structurally similar read across chemicals has been reviewed to determine the effect of the test chemical.The studies are as mentioned below:
In first study ,inhibitory effects of test chemical on micro organism species Bacillus spp. was observed using different soil and water samples as inoculum. Test chemical analytically monitorized by thin-layer chromatography. A stock solution (0.276 mg/ml) was prepared in methanol,with an activity of 36 512 dpm/ul). Methanol were used as a vehicle in which test chemical dissolved. Test conducted under the static system for 192 hrs. During experiment the Effect of benzimidazole derivatives on maximum growth of Bacillus strains was observed to be at concentrations 500-1000 mg/l (reported as ug/ml) using tubes shaken in water bath at 30C; Klett-Summerson readings taken at intervals up to 192 h after inoculation. Based on the EC50 value, chemical consider to be nontoxic.
The median effective concentration (EC50) for the test substance, in microorganism (Photobacterium phosphoreum) in a 5-30 minute study on the basis of viability and sensitivity effect was observed to be 86.4 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 86.4 mg/L
Additional information
Toxicity to microorganism:
Data available for the structurally similar read across chemicals has been reviewed to determine the effect of the test chemical.The studies are as mentioned below:
In first study ,inhibitory effects of test chemical on micro organism species Bacillus spp. was observed using different soil and water samples as inoculum. Test chemical analytically monitorized by thin-layer chromatography. A stock solution (0.276 mg/ml) was prepared in methanol,with an activity of 36 512 dpm/ul). Methanol were used as a vehicle in which test chemical dissolved. Test conducted under the static system for 192 hrs. During experiment the Effect of benzimidazole derivatives on maximum growth of Bacillus strains was observed to be at concentrations 500-1000 mg/l (reported as ug/ml) using tubes shaken in water bath at 30C; Klett-Summerson readings taken at intervals up to 192 h after inoculation. Based on the EC50 value, chemical consider to be nontoxic.
The median effective concentration (EC50) for the test substance, in microorganism (Photobacterium phosphoreum) in a 5-30 minute study on the basis of viability and sensitivity effect was observed to be 86.4 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)