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Diss Factsheets
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EC number: 232-260-8 | CAS number: 7803-51-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP but not a guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
- Principles of method if other than guideline:
- Sinlge 6 hour exposure but with 24 hours observation (not 14 days). Additional haematology examinations at sacrifice.
- GLP compliance:
- yes
- Test type:
- other: acute investigative
Test material
- Reference substance name:
- Phosphine
- EC Number:
- 232-260-8
- EC Name:
- Phosphine
- Cas Number:
- 7803-51-2
- Molecular formula:
- H3P
- IUPAC Name:
- phosphane
- Test material form:
- other: gas
- Details on test material:
- 1% phosphine in nitrogen
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Animals were individually housed in wire-mesh, stainless steel cages within a 1000 litre glass and stainless steel exposure chamber. The chamber was operated dynamically at a calibrated air-flow rate of 200 litres per minute (1pm); this provided a complete air change every 5 minutes and a 99% equilibrium time of 23 minutes. The test gas was delivered to the chamber via stainless steel tubing and additional air for dilution was drawn in via a HEPA filter. Air temperature, relative humidity and air-flow rate were recorded every 30 minutes.
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 6 h
- No. of animals per sex per dose:
- 5 males + 5 females at 0, 1.3, 6.0 and 28 ppm
10 males at 0, 3.1, 10 and 18 ppm - Control animals:
- yes
- Details on study design:
- Animals were given a single 6 hour whole body exposure; blood samples were taken prior to sacrifice on Day 2 for cytogenetic analysis. Haematology samples were taken from groups 0, 3 and 18 ppm. Blood sample analysis was done by a different laboratory and reported separately.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- other: mortalities
- Effect level:
- ca. 28 ppm
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Sex:
- male/female
- Dose descriptor:
- other: LOEL
- Effect level:
- ca. 10 ppm
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Sex:
- male
- Dose descriptor:
- other: NOEL
- Effect level:
- ca. 3 ppm
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Mortality:
- 3/5 males and 2/5 females given 28 ppm died.
- Clinical signs:
- other: Animals given 28 ppm appeared hunched, displayed tremors and decreased activity and were cold to touch; surviving animals in this group were unremarkable on Day 2. All other animals were unremarkable.
- Body weight:
- There was a decrease in bodyweight on Day 2 in animals exposed to 10, 18 or 28 ppm.
- Other findings:
- Mean haematology in the 0, 3, 10 and 18 ppm groups showed an increase in haemaglobin, haematocrit and erythrocyes at 10 and 18 ppm. There were no detectable Heinz bodies.
Any other information on results incl. tables
mean and nominal exposures were as follows: mean 0, 1.3, 6.0, 28, 0, 3.1, 10 and 18 ppm. nominal 0, 1.0, 5.4, 26, 0, 3.0, 12 and 18 ppm. Particle size distribution gave the mean mass median aerodynmaic diameter as 0.76 to 6.1 microns and particulate exposure was less than 7 ug/m3.
Applicant's summary and conclusion
- Interpretation of results:
- highly toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
Following 6 hours inhalation exposure to phosphine, 5/10 rats given 28 ppm died; transient observations of tremors, decreased activity, hunched appearance and cold to touch were also noted in this group. There were no deaths at 10 ppm. There was a transient decrease in bodyweight the day after exposure at 10, 18 and 28 ppm and changes in haematology.
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