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EC number: 700-810-0 | CAS number: 58190-62-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 15 March 2012-19 June 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The test procedure was well described in the study report, based on the EC, OECD and OPPTS hydrolysis test guidelines and performed according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Version / remarks:
- (2008)
- Deviations:
- yes
- Remarks:
- a test based on the guideline was performed
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- (2004)
- Deviations:
- yes
- Remarks:
- a test based on the guideline was performed
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.2120 (Hydrolysis of Parent and Degradates as a Function of pH at 25°C)
- Version / remarks:
- (2008)
- Deviations:
- yes
- Remarks:
- a test based on the guideline was performed
- Principles of method if other than guideline:
- Quick hydrolysis of the substance was expected. To confirm this, the following test was performed instead of the tests outlined in the test guidelines.
5 ml of the test substance was mixed with 10 and 25 ml of each buffer (pH 4, 7 and 9) in a glass vessel. Each vessel was inverted 10 times by hand and the phases were allowed to separate. 4 minutes and 1 hour after preparation, a sample was taken from the upper organic phase and analysed. Chromatograms of the pretreated samples were compared with a chromatogram of untreated test substance. The test was performed at room temperature. - GLP compliance:
- yes
Test material
- Test material form:
- other: Colourless to mild yellowish liquid
- Details on test material:
- - Name of test material (as cited in study report): OS 2600
- CAS no.: 58190-62-8
During performance of the test, the test substance and test substance containing solutions were protected from light as much as possible.
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- no
- Details on sampling:
- All test samples were analysed by single injection.
- Buffers:
- Acetate buffer pH 4, 0.1 M: solution of 16.7% (v/v) 0.1 M sodium acetate and 83.3% (v/v) 0.1 M acetic acid. The buffer contains 0.0009% (w/v) sodium azide.
Phosphate buffer pH 7, 0.1 M: solution of 0.1 M potassium dihydrogenphosphate adjusted to pH 7 using 10 N sodium hydroxide. The buffer contains 0.0009% (w/v) sodium azide.
Borate buffer pH 9, 0.1 M: solution of 0.1 M boric acid and 0.1 M potassium chloride adjusted to pH 9 using 10 N sodium hydroxide. The buffer contains 0.0009% (w/v) sodium azide.
Results and discussion
- Preliminary study:
- Several small and large peaks were observed in the chromatogram of the test substance solution. It was assumed that the large peaks derive from the major components of the test substance, whereas the small peaks derive from impurities. The peak area of the major components with a retention time between 5.5 and 6.5 minutes was used as response in the calculations.
Any other information on results incl. tables
Table Test substance response at pH 4, pH 7 and pH 9
Date of analysis |
Volume buffer solution [ml] |
pH code |
Sampling time [minutes] |
response [area] |
Relative concentration |
|
|
|
|
|
|
15-03-12 |
10 |
pH 4 |
n.a. |
5483201 |
|
|
|
|
4 |
31017 |
0.57 |
|
|
|
60 |
75758 |
1.4 |
|
|
|
|
|
|
21-03-12 |
10 |
pH 7 |
n.a. |
187320621 |
|
|
|
|
4 |
2522 |
0.01 |
|
|
|
60 |
0 |
0.00 |
|
|
|
|
|
|
21-03-12 |
10 |
pH 9 |
n.a. |
187320621 |
|
|
|
|
4 |
7335141 |
39 |
|
|
|
60 |
11049995 |
59 |
|
|
|
|
|
|
15-03-12 |
25 |
pH 4 |
n.a. |
5483201 |
|
|
|
|
4 |
0 |
0.00 |
|
|
|
60 |
1152 |
0.02 |
|
|
|
|
|
|
21-03-12 |
25 |
pH 7 |
n.a. |
187320621 |
|
|
|
|
4 |
0 |
0.00 |
|
|
|
60 |
0 |
0.00 |
|
|
|
|
|
|
21-03-12 |
25 |
pH 9 |
n.a. |
187320621 |
|
|
|
|
4 |
266090 |
1.4 |
|
|
|
60 |
102510 |
0.55 |
|
|
|
|
|
|
n.a. not applicable; response of untreated test substance
1 average of two measurements; individual peak areas were 17681703 and 19782420
Applicant's summary and conclusion
- Conclusions:
- A screening test based on EC C.7, OECD 111, EPA OPPTS 830.2120 guidelines and performed under GLP, showed that the substance hydrolysis very fast at room temperature and pH 4, 7 and 9 (half-life time < 4 minutes).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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