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Diss Factsheets
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EC number: 205-759-3 | CAS number: 150-39-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
It is considered highly likely that HEDTA will behave similarly to EDTA and on this basis it is expected to poorly absorb across the gastrointestinal tract and will be excreted rapidly and largely unchanged. Dermal absorption is expected to be minimal.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 10
- Absorption rate - dermal (%):
- 0.1
Additional information
There is limited information available on the toxicokinetics of HEDTA. The mode of action of the toxicity of these chemicals is considered to be due to their chelating capabilities and as such a higher chelating potential (and a large size) will reduce the potential for the compound to move across membranes and therefore reduce absorption and bioavailability of the compound. A review of the binding and ionisation potential of HEDTA and its structural analoge, EDTA, indicate that the behaviour of HEDTA and EDTA are similar (Dwibedy et al., 1999). The rate constants for the reaction of both chemicals with OH radicals indicate an increase with increase in pH, with an opposite trend observed in a small mid-region of pH (between 1 and 3).
There were no studies available on the absorption, metabolism, distribution or elimination (AMDE) for HEDTA. Toxicokinetic studies on humans and on rats indicate that the structural analogue, EDTA, is poorly absorbed across the gastrointestinal tract. The absorbed EDTA did not undergo any biotransformation and was rapidly excreted unchanged in urine. However it was noted that there is an increase in excretion of necessary ions such as Zn, Mn or Ca. It is considered that HEDTA will behave similarly to EDTA and on this basis it is expected to poorly absorb across the gastrointestinal tract and will be excreted rapidly and largely unchanged.
In a study on young, healthy, male volunteers Foreman etal (1954) investigated the dermal absorption of CaNa2 -EDTA. 3 mg of a mixture of14C labelled and unlabeled substance was prepared in a water soluble base which was applied over an area of 100 cm2 for 24 hours under occlusive conditions. The maximum activity in the urine was 0.001% of the administered dose.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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