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EC number: 234-439-6 | CAS number: 12003-78-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The 48 hour LD50 (oral) is calculated at greater than 31,600 mg/kg in the rat.
The 48 hour LC50 (inhalation) is calculated at greater than 2 µg/m³ in the rat.
The 48 hour LD50 (dermal) is calculated at greater than 2 mg/kg in the rabbit.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic information is given
- Qualifier:
- according to guideline
- Guideline:
- other: Guidelines of the Department of Transportation (D.O.T.), Code of Federal Regulations, Title 49, Part 173
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - healthy albino rats
- weighing 100 - 150 gr
- animals were housed five per wire mesh suspended cage - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Based on the range finding results, five male and five female rats were gavaged in a similiar manner, see preliminary study.
- Doses:
- 31,600 mg/kg bw
- No. of animals per sex per dose:
- 5 animals per sex
- Control animals:
- no
- Details on study design:
- Body weights were recorded at dosing and at 48 hours for the survivors.
Clinical signs were noted immediately after dosing and at 4, 24 and 48 hours.
Animals found dead or terminated at 48 hours were subjected to a macroscopic examination of the viscera. - Statistics:
- LD50 was calculated according to the method of Litchfield and Wilcoxon, Pharmacol. and Exp. Ther., 96:99, 1949
- Preliminary study:
- Following a 7-day period, a series of range finding doses were given by gavage to rats fasted overnight.
Doses in the range finding:
No. Dead/No. Dosed
10,000 mg/kg bw 0/2
6,320 mg/kg bw 0/2
3,980 mg/kg bw 0/2 - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 31 600 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Results of Main Study
No. Dead/No. Dosed
31,600 mg/kg bw 0/10 - Clinical signs:
- other: Animals at the highest dose appeared normal after dosing.
- Gross pathology:
- Macroscopic changes were not observed in the viscera.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Conclusions:
- The 48 hour LD50 is calculated at greater than 31,600 mg/kg in the rat.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 31 600 mg/kg bw
- Quality of whole database:
- RL 2
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic information is given
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- 10 animals
provided with Purina cubed diet and tap water ad libitum
acclimation: 7 days - Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Details on inhalation exposure:
- dust-laden air was piped to a 56 liters all glass exposure chamber with the test animal.
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 1 h
- Concentrations:
- Nominal chamber concentration was 25 mg/L
Measured concentration was 2.2 mg/L - No. of animals per sex per dose:
- 10
- Control animals:
- no
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 2 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- All animals were considered normal through out the 14d oberservation period.
- Clinical signs:
- other: No signs of toxicity were obeserved under the test conditions.
- Body weight:
- No abnormal body weight gains were observed.
- Gross pathology:
- Observed at necropsy at 14d post-exposure: Increased incidence of pulmonary abnormalities such as areas of hemorrhage and atelectasis. Was considered to be moderate.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Conclusions:
- No signs of toxicity were observed under test conditions.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 2.2 µg/m³ air
- Quality of whole database:
- RL2
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic information is given
- Qualifier:
- according to guideline
- Guideline:
- other: Guidelines of the Department of Transportation (D.O.T.), Code of Federal Regulations, Title 49, Part 173
- GLP compliance:
- not specified
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- other: New Zealand
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- - healthy albino rabbits
- weighing ca. 3 kg
- animals were individually housed in stainless steel supended cages. - Type of coverage:
- other: see details on study design
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The test item was applied at 2mg/kg of body weight to the shaved skin and wrapped with an impervious band which has left in place for 24 hours.
- Duration of exposure:
- Animals were observed for mortality for up to 48 hours.
- Doses:
- 2 mg / kg /bw
- No. of animals per sex per dose:
- 5 animals / abraded skin
5 animals / intact skin
same doses to all, see above - Control animals:
- no
- Details on study design:
- After a 7-day acclimation period, ten rabbits were clipped free of fur over the entire upper back area. Rabbits showing signs of dermal irritation or lesions were replaced. Five of the tesat sites were abraded by making a series of five parallel superficial scracthes in the dermis; the reminaing five were left intact.
Body weights were recorded at dosing.
Treatment sites were evaluated for signs of erythema or edema according to the Draize Scoring System. - Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths were noted up to 48 hours after application.
- Clinical signs:
- other: No changes were noted in skin condition during the test period.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Conclusions:
- The 48 hour LD50 is calculated at greater than 2 mg/kg in the rabbit.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 mg/kg bw
- Quality of whole database:
- RL 2
Additional information
Test item did noch show any acute oral or dermal toxicity.
Justification for selection of acute toxicity – oral endpoint
only available study
Justification for selection of acute toxicity – inhalation endpoint
only available study
Justification for selection of acute toxicity – dermal endpoint
only available study
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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