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EC number: 407-000-3 | CAS number: 127519-17-9 CGL 384; TINUVIN 384
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
According to Annex XI of Regulation (EC) 1907/2006 substances whose physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity may be considered as a group, or “category” of substances. Application of the group concept requires that physicochemical properties, human health effects and environmental effects or environmental fate may be predicted from data for reference substance(s) within the group by interpolation to other substances in the group (read-across approach). The similarities may be based on (1) a common functional group, (2) the common precursors and/or the likelihood of common breakdown products via physical and biological processes, which result in structurally similar chemicals or (3) a constant pattern in the changing of the potency of the properties across the category.
The read-across substance (EC 400-830-7) consists of two major components: (1) a monoester component present at 51 w/w% and (2) a diester component present at 35.4 w/w%. Both the read-across compound and EC 407-000-3 share the same phenolic benzotriazole core structure with a hydroxyl group at position 2 and a tertiary butyl group at position 3 of the phenyl group. At position 5 of the phenyl ring a CH2-CH2-COO group is connected to a (C2H4O)n group (n is typically in the range of 2 to 10). Both the monoester and the diester are highly similar to EC 407-000-3, especially the phenolic benzotriazole core structure which is identical in the respective compounds. The only structural difference is the side chain connected to the carboxylic moiety. Due to the carboxylic moiety and the ester linkage to the side chain the compounds are susceptive to hydrolysis and further degradation processes. The primary degradant of both the diester and the monoester are therefore highly similar/identical to the degradant of EC 407-000-3.
Although the water solubility of the monoester (monoester: 1.74 mg/L; diester: <0.2 mg/L) differ from the solubility of EC 407-000-3 (0.018 mg/L) it can be stated that both substances have low solubilities. However, more important for the assessment of terrestrial toxicity is the ability to adsorb to soil. Both the components of the read-across substance and EC 407-000-3 strongly adsorb to the solid soil phase indicated by high logKoc (monoester: 4.1; diester: 4.2; EC 407-000-3: 5.9) and logKow (monoester: 5.9; diester: 4.6; EC 407-000-3: 9.2) values. Therefore a similar distribution pattern in the environment is expected for both substances and the uptake is expected to take place mainly via the solid soil phase and not the soil pore water.
In summary, taking into account the common functional core structure as well as the common breakdown product via physical and biological processes a read-across from EC 400-830-7 to EC 407-000-3 is regarded as suitable. Furthermore, due to the physico-chemical properties a similar distribution pattern in the environment is expected.
A guideline study on Eisenia fetida following OECD guideline 207 is available. The animals were placed on artificial soil mixed with the test substance. The exposure period was 14 days. At test termination the mortality of the test animals were recorded and a LC50 > 1000 mg/kg soil dw (LC0 > 1000 mg/kg soil dw) was determined (Ciba-Geigy Ltd., 1987).
Furthermore, a guideline study on Eisenia fetida following OECD guideline 222 (Effects on reproduction and growth of earthworms Eisenia fetida in artificial soil) is available. The overall exposure period was 8 weeks. Mortality and growth effects on the adult worms were determined after 4 weeks of exposure. The adults were then removed from the soil and effects on reproduction assessed after a further 4 weeks. The corresponding NOEC were 1000 mg/kg soil dw for mortality and 100 mg/kg soil dw for reproduction (Ciba Inc. 2009).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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