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EC number: 440-050-4 | CAS number: 243857-97-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Oct. 12, 1999 to Nov. 08, 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Analysis of the only test concentration plus a control at test start and after 48 h of exposure.
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method of administration: Direct weighing - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Strain: Daphnia magna STRAUS, parthenogenetic females
- Source: Laboratory bred at Bayer AG Leverkusen
- Age at study initiation (mean and range, SD): 0-24 h - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- None
- Post exposure observation period:
- No
- Hardness:
- 14.5 °dH
- Test temperature:
- 20.1 °C
- pH:
- 8.0-8.1
- Dissolved oxygen:
- 8.5-8.6 mg/L (48 h)
- Nominal and measured concentrations:
- Nominal: 0 and 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Cylindrical test vessels
- Material, size, headspace, fill volume: diameter 4.0 cm, height 6.5 cm, 20 mL test medium
- Aeration: No
- Renewal rate of test solution: No
- No. of organisms per vessel: 10 daphnids/vessel
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Keeping water: M4-Medium according to Elendt and BGA (1992)
- Method of administration: Direct weighing
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: M4-Medium according to Elendt and BGA
OTHER TEST CONDITIONS
- Photoperiod: 16 h light/8 h dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Number of immobile daphnids after 24 h and 48 h
TEST CONCENTRATIONS
- Range finding study
- Test concentrations: 0, 100 mg/L - Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 105.5 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- >= 68.6 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mobility
- Details on results:
- - Other biological observations: No
- Mortality of control: No - Validity criteria fulfilled:
- yes
- Conclusions:
- Under the test conditions, the 48 h EC0 value of the test substance (including inorganic components) was determined to be 105.5 mg/L.
- Executive summary:
A study was performed to assess the acute toxicity of test substance to Daphnia magna under static conditions. The study was conducted in accordance with EU Method C.2. in compliance with GLP.
Daphnids were exposed to a limit test concentration of 100 mg/L of test substance dissolved in water. Analysis was performed for the test concentration plus a control at the test start and after 48 h of exposure.
Observations were made on the immobilisation rate, after 24 and 48 h of exposure.
Under the test conditions, the 48 h EC0 value of the test substance (including inorganic components) was determined to be 105.5 mg/L.
Reference
Table 1. Study Results
After 24 h Nominal concentration |
After 48 h Arithmetic mean of analytical values |
EC0:≥100 mg/L |
≥ 68.6 mg/L organic components |
1800 |
≥ 68.6 mg/L (test substance; including inorganic components) |
The above test result refers to a concentration of the test substance which was calculated directly from analytically determined TOC values. According to the relevant product information, 1 mg/L TOC equals to 2.8 mg/L of the organic components of the test substance (structural formula: C23H21CIN6014S4; molecular weight 769.16 g/mol (free acid).
As these organic components correspond to 65 % of the molecular weight of the test substance, 100 mg/L of the test Substance equals to 23 mg/L of organic C. Thus, the above analytical values indicate a very good recovery rate.
Description of key information
The 48 h EC0 value of the test substance was determined to be 105.5 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- > 100 mg/L
Additional information
A study was performed to assess the acute toxicity of test substance to Daphnia magna under static conditions. The study was conducted in accordance with EU Method C.2.
Daphnids were exposed to a limit test concentration of 100 mg/L of test substance dissolved in water. Analysis was performed for the test concentration plus a control at the test start and after 48 h of exposure.
Observations were made on the immobilisation rate, after 24 and 48 h of exposure.
The 48 h EC0 value of the test substance (including inorganic components) was determined to be 105.5 mg/L (Dr. Caspers, 1999).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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