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EC number: 200-831-0 | CAS number: 75-01-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: In this record studies on acute inhalation toxicity and CNS effects of vinyl chloride in humans are combined. The studies have been published in peer-reviewed literature and are considered adequate for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Effects of single and repeated exposures of humans and rats to vinyl chloride.
- Author:
- Lester, D., Greenberg, L.A. and Adams, W.R.
- Year:
- 1 963
- Bibliographic source:
- Am Ind Hyg Assoc J 24:265-275
- Reference Type:
- publication
- Title:
- Toxicology Update: Vinyl Chloride
- Author:
- Easter, M.D., Von Burg, R.
- Year:
- 1 994
- Bibliographic source:
- J Appl Toxicol 14:301-307
- Reference Type:
- publication
- Title:
- Accidental Poisoning by Vinyl Chloride: Report of Two Cases
- Author:
- Danziger H.
- Year:
- 1 960
- Bibliographic source:
- Canad. M.A.J. 82, 828 - 830
Materials and methods
- Endpoint addressed:
- acute toxicity: inhalation
Test material
- Reference substance name:
- Chloroethylene
- EC Number:
- 200-831-0
- EC Name:
- Chloroethylene
- Cas Number:
- 75-01-4
- Molecular formula:
- C2H3Cl
- IUPAC Name:
- chloroethene
Constituent 1
Results and discussion
Any other information on results incl. tables
Method
Three men (26, 35, 50 years; 86, 78, 71 kg) and three women (25, 40, 55 years; 64, 52 61 kg) were exposed twice each day (separated by a 6-hour interval) for 3 successive days to six different concentrations of vinyl chloride: 0.0, 0.4, 0.8, 1.2, 1.6 and 2.0% (at random) via a plastic breathing mask affixed over the face (covering the mouth and nose). The rate of air or air-gas mixture was sufficient (50 litres per min) to prevent any dilution effects from the atmosphere. Exposures were terminated after 5 minutes and the subjects were asked to compare their feelings before and after taking off the masks.
Results
One subject reported
feeling dizzy after 0% and 0.8% (same subject). No effects were noted
at 0.4%. Two out of the 6 reported dizziness at 1.2%. Five out of 6
reported dizziness, light-headedness, nausea, and dulling of visual and
auditory cues at 1.6%, (which disappeared after cessation of exposure).
All subjects were intoxicated by 2.0%. The same symptoms were observed
as those caused by 1.6%, although they appeared earlier in the exposure
and were more intense. One subject reported a headache that persisted
for 30 minutes.
According to the authors, the maximum concentration causing no effect in
any subject lies between 0.8 and 1.2% (8000-12,000 ppm).
Reference:
Lester, D., Greenberg et al.(1963)
Method
Two experimenters were exposed to a VC concentration of 2.5 % for three minutes.
Results
Reversible dizziness,
slight disorientation, burning sensation of the feet. Immediate recovery
upon leaving the chamber. Slight headache for about 30 minutes.
Reference:
Easter M.D. et al. (1994)
Methods
Accidental exposure of three workers (VC polymerization plant) is reported.
Results
Two of the workers were found dead on the plant (unrelated cases). Autopsy did not reveal any specific diagnostic features. One person recovered after experiencing symptoms of a narcotic effect.
Reference
Danziger H. (1960)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.