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Diss Factsheets
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EC number: 201-143-3 | CAS number: 78-79-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Using a weight of evidence approach, isoprene is expected to be rapidly biodegradable and potentially readily biodegradable.
In a key study, conducted in accordance with OECD TG 301F and GLP. An average of 61% degradation was observed across 3 replicates which also met the 10 -day window which in most circumstances would mean the substance can be classified as readily biodegradable. However, the variability between the replicates exceeded 20% which according to the guidelines warrants a repeat of the test. Therefore, this test demonstrated the ability for isoprene to rapidly degrade but the data are insufficiently robust enough to support a conclusion of ready biodegradability. It should however be noted that it is not possible for this test to show a false positive due to the strict nature of the test conditions and so this study shows a strong possibility for the substance to be readily biodegradable.
Supporting studies are also available that show the substance could potentially be readily biodegradable. In an additional OECD TG 301D Closed Bottle test, 60% biodegradation was measured in one replicate on day 18. On day 28, the average biodegradation between two replicates (2 and 58%) was 30%. Therefore, the criteria for ready biodegradability were not met. A maximum extent of 64% biodegradation was measured on day 7 of a supplementary investigation, which confirms that isoprene can be rapidly biodegraded in the presence of an acclimated inoculum. The test substance showed no inhibitory effect on the normal degradative activity of the microbial inoculum in the supplementary study.
This is further supported by QSAR modelling using the Biowin and BioHCwin models which show the substance is likely to be readily biodegradable.
In conclusion. the substance is considered readily biodegradable based on the strong evidence in the key study that it is potentially readily biodegradable, which is supported by the supplementary studies and QSAR models.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.