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Diss Factsheets
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EC number: 203-450-8 | CAS number: 106-99-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non-guideline study, published in peer reviewed literature, restrictions in design and/or reporting.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Concentrations of hydrocarbons in tissues as a measure of toxicity,
- Author:
- Shugaev B
- Year:
- 1 969
- Bibliographic source:
- Arch. Environ. Health, 18, 878-882.
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- no
- Remarks:
- predates GLP
- Test type:
- other: LC50s but no method details
- Limit test:
- no
Test material
- Reference substance name:
- Buta-1,3-diene
- EC Number:
- 203-450-8
- EC Name:
- Buta-1,3-diene
- Cas Number:
- 106-99-0
- Molecular formula:
- C4H6
- IUPAC Name:
- buta-1,3-diene
- Reference substance name:
- 1,3-Butadiene
- Cas Number:
- 106-99-0
- Molecular formula:
- C4H6
- IUPAC Name:
- 1,3-Butadiene
- Details on test material:
- 1,3-Butadiene (source and purity not specified)
Constituent 1
Constituent 2
Test animals
- Species:
- other: rat and mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not given
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: air
- Details on inhalation exposure:
- Described as "dynamic flow exposure"
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- >= 2 h
- Remarks on duration:
- Rats were exposed for 4h mice were exposed for 2h
- Concentrations:
- Specific concentrations not given
- No. of animals per sex per dose:
- Not specified
- Control animals:
- not specified
- Details on study design:
- see below
- Statistics:
- see below
Results and discussion
- Preliminary study:
- Not applicable
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 285 other: mg/L air (285, 000 mg/m3)
- Exp. duration:
- 4 h
- Remarks on result:
- other: rat
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 270 other: mg/L (270,000 mg/m3)
- Exp. duration:
- 2 h
- Remarks on result:
- other: mice
- Mortality:
- None
- Clinical signs:
- other:
- Body weight:
- Not determined
- Gross pathology:
- Not determined
- Other findings:
- none
Any other information on results incl. tables
Rat LC50 (4
hr) = 285 mg/L; confidence limits 219 -370 mg/L (p<0.05).
Mouse LC50 (2 hr) = 270 mg/L; confidence limits 251-290 mg/L (p<0.05).
Toxic effects are described in Shugaev, B.B. (1968), Farmakol. Toksikol. (Moscow) 31,162-165. There was a rapid onset of narcosis. This was reversible, after 30min withdrawal from treatment all animals returned to normal. At lethal concentrations breathing become shallower, rarer and periodic.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- This is an old non-guideline study that is not up to current standards, but there are few acute toxicity studies available on 1,3-butadiene. However LC50s were reported to be 285 mg/L for 4h (285,000 mg/m3) in rats, 270 mg/L for 2h (270,000mg/m3) in mice.
- Executive summary:
Rats and mice were exposed to 1,3-butadiene for 4h or 2h respectively. There was a rapid but reversible onset of narcosis. LC50 values were reported to be 285 mg/L (285,000 mg/m3) in rats and 270 mg/L (270,000 mg/m3) in mice.
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