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Diss Factsheets
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EC number: 200-580-7 | CAS number: 64-19-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
Data source
Reference
- Reference Type:
- publication
- Title:
- Statistical analyses on the pattern of food consumption and digestive-tract cancers in Japan
- Author:
- Hara N, Sakata K, Nagai M, Fujita Y, Hashimoto T and Yanagawa H
- Year:
- 1 985
- Bibliographic source:
- Nutrition and Cancer, Vol 6, pp 220-228
Materials and methods
- Study type:
- cross sectional study
- Endpoint addressed:
- carcinogenicity
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Cancer mortality data for 6 digestive-tract cancers were acquired for males from different Japanese regions for a 10 year period starting in 1969. Data on food consumption were obtained from the Fourth National Survey of Family Income and Expenditures (1974) and 26 food items, including vinegar (acetic acid) were chosen to include those commonly eaten and those suspected to have an association with cancer. Various statistical analyses were conducted to correlate the standardised mortality ratio with different sites of cancer and food variables in the different regions.
- GLP compliance:
- no
Test material
- Reference substance name:
- Vinegar
- IUPAC Name:
- Vinegar
- Details on test material:
- - Name of test material (as cited in study report): Vinegar
- Other: no other details reported
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not applicable
- Details on study design:
METHOD OF DATA COLLECTION
- Type: Record review
- Details: Cancer mortality data for 6 digestive-tract cancers were aquired from standardised cancer mortality ratios on a prefectural basis.
STUDY PERIOD: 10 year period starting in 1969.
SETTING: Japan
STUDY POPULATION
- Males in general population in 46 Japaense prefectures.
HEALTH EFFECTS STUDIED
- Disease(s): Six digestive-tract cancers - oesophagus, stomach, colon, rectum, biliary passages and pancreas.
- Exposure assessment:
- estimated
- Statistical methods:
- Correlations between the SMR for the 6 different cancer sites and 26 food variables were calculated and also correlations were calculated between the cancer SMR in different prefectures for the six cancer sites. Factor analysis of the 26 food variables was performed to reduce the number of variables and correlations were calculated between the factors derived from the factor analysis and the cancer SMR.
Results and discussion
- Results:
- Vinegar showed a negative correlation with the SMR for all digestive-tract cancers examined (oesophageal, stomach, colon, rectal, biliary passsages and pancreatic cancers).
- Confounding factors:
- No adjustment was made for confounding factors
- Strengths and weaknesses:
- Strengths: Hypothesis generation
Weaknesses: The study only correlated SMR and food consumption values for prefectures. No adjustments were made for potential confounding factors or other food items consumed. No information was supplied about the number of people surveyed in each prefecture to obtain information about the consumption of the 26 food items, and levels of consumption during the middle of the study period (1974) may not have reflected more relevant exposures several years previously. Vinegar consumption only accounts for about a tenth of acetic acid intake and hence results cannot be extrapolated to acetic acid consumption.
Applicant's summary and conclusion
- Conclusions:
- Consumption of vinegar in Japan was negatively associated with standardised mortality ratios for all cancers of the gastro-intestinal tract, including bile ducts and pancreas.
- Executive summary:
In an epidemiological study comparing of local food consumption patterns in Japan with geographical distributions of gastro-intestinal cancers, vinegar consumption was shown to be negatively associated with standardised mortality ratios for all cancers of the gastro-intestinal tract, including bile ducts and pancreas.
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