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Diss Factsheets
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EC number: 202-966-0 | CAS number: 101-68-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report with restrictions due to limited reporting
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- A one-week acute intraperitoneal toxicity test was carried out to decide the dose level for the micronucleus test. Groups of 5-6 male mice were treated with the test material at different dose levels in 3 series of experiments, and LD50 was estimated from the number of deaths.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 4,4'-methylenediphenyl diisocyanate
- EC Number:
- 202-966-0
- EC Name:
- 4,4'-methylenediphenyl diisocyanate
- Cas Number:
- 101-68-8
- Molecular formula:
- C15H10N2O2
- IUPAC Name:
- 1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene
- Details on test material:
- - Name of test material (as cited in study report): 4,4'-Diphenylmethane diisocyanate
- Analytical purity: not reported
- Impurities (identity and concentrations): not reported
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: DMSO and corn oil
- Details on exposure:
- - Preparation of test material: MDI is insoluble in water and reacts with it to form polymers. Therefore, the test material was dissolved in a small amount of dimethylsulfoxide (DMSO), the first solvent, which does not contain water, and then it was suspended in the sterilized corn oil, the second solvent.The preparation was made separately for each test and used immediately.
- Doses:
- Experiment I: 10, 20, 100 and 500 mg/kg bw;
Experiment II: 133, 200, 300 and 450 mg/kg bw;
Experiment III: 89, 133 and 200 mg/kg bw - No. of animals per sex per dose:
- 5 in Experiment I
6 in Experiment II and III - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 100 mg/kg bw
- Mortality:
- see free text
Any other information on results incl. tables
Experiment No. |
Dose levels (mg/kg bw) |
No. of animals died/ No. of animals treated |
Time of death (day) |
|||
0-1 |
1-3 |
3-5 |
5-7 |
|||
1 |
500 |
5/5 |
0 |
3 |
2 |
0 |
100 |
0/5 |
0 |
0 |
0 |
0 |
|
20 |
0/5 |
0 |
0 |
0 |
0 |
|
10 |
0/5 |
0 |
0 |
0 |
0 |
|
2 |
450 |
4/6 |
0 |
3 |
1 |
0 |
300 |
5/6 |
0 |
2 |
1 |
2 |
|
200 |
5/6 |
0 |
4 |
1 |
0 |
|
133 |
4/6 |
0 |
2 |
0 |
2 |
|
3 |
200 |
5/6 |
0 |
2 |
3 |
0 |
133 |
4/6 |
0 |
1 |
1 |
2 |
|
89 |
0/6 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.