Propan-2-ol

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1977

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Not GLP, no guideline followed, although it is similar to the most recent OECD 202 with some deviations, which did not affect results. It contains all the information necessary for the evaluation. Peer-reviewed article, it reports the LC50(24h) of 173 substances.

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Deviations:

yes

Remarks:

10 animals per conc. Test period 24 h. Oxygen concentration not measured. No controls.

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

24 h

Duration:

24 h

Dose descriptor:

LC50

Effect conc.:

> 10 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Duration:

24 h

Dose descriptor:

LC0

Effect conc.:

5 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Validity criteria fulfilled:

not specified

Conclusions:

The LC50(24 h) of 2-propanol in the Daphnia sp. acute immobilisation test is: > 10000 mg/L

Executive summary:

The 24 hour LC50 of 173 substances hazardous in water was determined by means of a standardized procedure using 24-h-old animals from a clone of Daphnia magna. At the same time, the LC0 and LC100 for each of these pollutants were determined. The test medium was tap water free from chlorine, saturated with oxygen, hardness 16° dH (German), pH 7.6 – 7.7, temperature 20 - 22°C.

Description of key information

The substance was not acutely toxic to Daphnia magna when tested according to OECD guideline 202 (Daphnia sp. Acute Immobilisation Test), the substance was determined to possess a 24 hour LC50 of 9714 to 10000 mg/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

10 000 mg/L

Additional information

Three studies addressing short-term toxicity to aquatic invertebrates are presented in the dossier. 

Short-term toxicity to aquatic invertebrates.001 – daphnia -1977 – key: Acute toxicity to Daphnia magna was assessed according to OECD guideline 202 (Daphnia sp. Acute Immobilisation Test) not according to GLP (pre-dates GLP requirements). Daphnia were exposed under static conditions to the substance for 24 hours. The 24-hour EC₅₀ for Immobility was determined to be >10,000 mg/L.

Short-term toxicity to aquatic invertebrates.002 – daphnia – 1982: Acute toxicity to Daphnia magna was assessed not according to specific guidelines but is similar to the OECD guideline 202 (Daphnia Sp. Acute Immobilisation Test). The daphnia were exposed to the substance under static conditions for 24 hours. The 24 hour EC₅₀ was determined to be 9714 mg/L.

Short-term toxicity to aquatic invertebrates.003 – shrimp – 1974: Acute toxicity to Crangon crangon (Shrimp) was assessed not according to specific guidelines but is similar to the OECD guideline 202 (Daphnia Sp. Acute Immobilisation Test). The animals were exposed to the substance under semi-static conditions in saltwater for 96 hours. The 96 hour LC₅₀ was determined to be 1150 ppm.