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Diss Factsheets
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EC number: 256-032-2 | CAS number: 42978-66-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Contact sensitivity to acrylate compounds in guinea pigs
- Author:
- Parker D, Turk JL
- Year:
- 1 983
- Bibliographic source:
- Contact Dermatitis 9: 55-60
Materials and methods
- GLP compliance:
- no
- Type of study:
- other: Contact skin reactions in guinea pigs immunized by the Polak method
- Justification for non-LLNA method:
- At the time of the study, the LLNA method has not been established.
Test material
- Reference substance name:
- (1-methyl-1,2-ethanediyl)bis[oxy(methyl-2,1-ethanediyl)] diacrylate
- EC Number:
- 256-032-2
- EC Name:
- (1-methyl-1,2-ethanediyl)bis[oxy(methyl-2,1-ethanediyl)] diacrylate
- Cas Number:
- 42978-66-5
- Molecular formula:
- C15 H24 O6
- IUPAC Name:
- (1-methyl-1,2-ethanediyl)bis[oxy(methyl-2,1-ethanediyl)] diacrylate
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Royal College of Surgeons or David Hall, Newchurch, Staffordshire, England
- Weight at study initiation: 400-500 g
- Diet (e.g. ad libitum): Labsure RGP diet liberally supplemented with cabbage and hay
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal
- Vehicle:
- other: ethanol:saline 1:4 or acetone:olive oil 4:1
Challenge
- Route:
- epicutaneous, open
- Vehicle:
- other: ethanol:saline 1:4 or acetone:olive oil 4:1
- No. of animals per dose:
- 6 animals were used in total
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: Time of first positive skin test
- Group:
- test chemical
- Dose level:
- 0.5%, 1%
- Total no. in group:
- 6
- Remarks on result:
- other: Results are expressed as the average intensity of the skin reactions at a certain skin test concentration, of all the animals .
Any other information on results incl. tables
The skin test concentrations were 0.5% and 1%. The first positive skin test was observed after 28 days. The test substance was judged to be a weak sensitizer.
|
|
|
Skin test concentrations |
|
Compound |
No. of animals |
Timea) |
0.5% |
1% |
Test substance |
6 |
28 days |
0.4 |
1.1b) |
a) Time of first positive skin test
b) Results are expressed as the average intensity of the skin reactions at a certain skin test concentration, of all the animals .
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (skin sensitising) based on GHS criteria
- Conclusions:
- Based on the study results the test substance is a skin sensitizer Cat. 1.
- Executive summary:
In this non GLP study, contact skin reactions were investigated using guinea-pigs that were immunized by the Polak method (1983a). On day 7, the animals received 4 footpad injections of 0.1 ml of an emulsion containing 2 mg/ml of the chemical, in ethanol:saline (1:4), in Freund's complete adjuvant (FCA - Difco mycobacterium butyricum). In addition, 0.1 ml of the emulsion was injected into the nape of the neck . The guinea pigs received a total of 1 mg of chemical. On day 7, open skin testing was performed by dropping 0.02 ml of a solution of the chemical in acetone:olive oil (4:1) onto the shaved flank. The concentration of the skin test solution varied with the chemical and those used were dilutions of 5% or the maximum concentration which gave no non-specific irritation. Skin tests were repeated weekly at different sites on the flank for up to 12 weeks. The skin test concentrations were 0.4% and 1.1%. The first positive skin test was observed after 28 days. The test substance was judged to be a weak sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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