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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 209-008-0 | CAS number: 552-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Dermal absorption
Administrative data
- Endpoint:
- dermal absorption, other
- Remarks:
- in silico
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Study period:
- February 26, 2016
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
Data source
Referenceopen allclose all
- Reference Type:
- other: software
- Title:
- Unnamed
- Year:
- 2 014
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
Test guideline
- Guideline:
- other: ECHA Guidance on information requirements and chemical safety assessment - Chapter R.06: QSARs and grouping of chemicals
- Principles of method if other than guideline:
- The rate of mass build-up (or loss) on the skin comes from the deposition rate onto the skin minus the absorption rate into the Stratum Corneum (SC) and the amount evaporating from the skin to the air.
IH Skin Perm provides two primary dermal exposure modes to the modeler. The first is “instantaneous deposition” in which the substance is assumed to be on the skin as the result of a single exposure event. The second is “deposition over time” in which the substance is assumed to be applied at a constant rate over time. In the first case (instantaneous deposition) the above Deposition Rate is zero and IH Skin Perm then works to keep track of this single dose over time as it is absorbed into the SC or evaporates from the surface of the skin. In the second case (deposition over time) the rate of the substance going to the skin is assumed constant and the thickness of the film on the skin will either increase or decrease with time depending on the relative rates of deposition and removal.
The user inputs the amount going onto the skin as a single dose or as a constant rate and IH SkinPerm calculates the amount of chemical absorbed into the SC over time until all the material disappears from the surface via absorption and evaporation or the exposure is considered to be over.
Ultimately, the program estimates the amount of chemical absorbed into the systemic circulation of the body using clearly defined assumptions.
IH SkinPerm does all of this using relatively few physical chemical inputs for the substance. The details of these calculations are all available from Dr. ten Berge [(ref: specific documents (http://home.planet.nl/~wtberge/qsarperm.html)].
Test material
- Reference substance name:
- Benzene-1,2,4-tricarboxylic acid
- EC Number:
- 208-432-3
- EC Name:
- Benzene-1,2,4-tricarboxylic acid
- Cas Number:
- 528-44-9
- Molecular formula:
- C9H6O6
- IUPAC Name:
- benzene-1,2,4-tricarboxylic acid
Constituent 1
Results and discussion
Percutaneous absorption
- Time point:
- 4 h
- Dose:
- Deposition dose: 7939 mg
- Parameter:
- rate
- Remarks:
- absorbed
- Absorption:
- <= 0.001 mg cm-2 h-1
Any other information on results incl. tables
DATA INPUT
Substance
EC name: benzene-1,2,4-tricarboxylic acid
CAS number: 528-44-9
Molecular weight: 210.14
Temperature: 25°C
Vapour Pressure: 1.4E-06 Pa
Water solubility: 24400 mg/L
Log Kow (skin, pH= 5.5): -3.34
Density: 1654 mg/cm3(published data)
Scenario parameters
Instantaneous deposition
· Deposition dose*: 7939 mg
· Affected skin area**: 1000 cm2
· Thickness of stagnant air***: 1 cm
Timing parameters
· Start deposition: 0 hr
· End time observation: 4 hr
Report parameters
· Calculationintervals/hours: 7200
· Report intervals/hours: 60
* Approximately 2 mL of a liquid having a viscosity similar to water will practically wet the palms of two hands (ca. 420 cm2). So 4.8 mL will wet all the skin surface of both hands. Ii is reasonably expected more liquid will be excess and wash/fall off.
** Estimated skin surface of two hands of an adult.
*** Nude skin.
RESULTS
Deposition: Instantaneous
Tot. Deposition: 7939 mg
End time observation: 4 hr
Fraction absorbed: 0.1%
Amount absorbed: 5.8 mg
Lag time stratum corneum: 133.2 min.
Max. derm. abs.: 7.33E-04 mg/cm2/hr
Max. derm. abs. for 2000 cm2in 1 hour (from liquid): 1.47 mg
Dermal/Respiratory uptake ratio (from airborne vapour): R= 4.157
R= RX/X
RX: total dermal absorption by dermal exposure to airborne vapour
X: total inhalation absorption from airborne vapour
Assuming that Fully Respiratory Protection provides 100% efficiency:
Protection from respirator= 100*X/(RX+X)= 100/(R+1)= 100/5.157= 19.4% protection against overexposure to the substance in the form of vapour due to dermal vapour absorption over whole body surface.
Applicant's summary and conclusion
- Conclusions:
- The dermal absorption of the test material leads to the following results, obtained using the SkinPerm v1.21 model, according to the input data:
Fraction absorbed: 0.1%
Amount absorbed: 5.8 mg
Lag time stratum corneum: 133.2 min.
Max. derm. abs.: 7.33E-04 mg/cm2/hr
Max. derm. abs. for 2000 cm2 in 1 hour (from liquid): 1.47 mg
Dermal/Respiratory uptake ratio (from airborne vapour): R= 4.157 - Executive summary:
In-silico evaluation of dermal absorption indicates that after 4 hours only a very small amount of deposited substance is absorbed within viable epidermis and therefore enter in systemic circulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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