Registration Dossier
Registration Dossier
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EC number: 203-804-1 | CAS number: 110-80-5
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Absorption of Some Glycol Ethers Through Human Skin in Vitro
- Author:
- Dugard, P.H. et al.
- Year:
- 1 984
- Bibliographic source:
- Environ. Health Perspect. 57, 193-197
Materials and methods
- Study type:
- other: skin permeability measurements
- Principles of method if other than guideline:
- Method: other: in vitro permeability measurements in human skin
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-ethoxyethanol
- EC Number:
- 203-804-1
- EC Name:
- 2-ethoxyethanol
- Cas Number:
- 110-80-5
- Molecular formula:
- C4H10O2
- IUPAC Name:
- 2-ethoxyethan-1-ol
- Details on test material:
- Name of the test substance as stated in the publication: 2-ethoxyethanol;
purchased from: ICI Petrochemicals and Plastics Division (Wilton UK);
purity: > 98 %
Constituent 1
Results and discussion
Any other information on results incl. tables
The absorption of the test substance achieved maximum steady rates within the experimental period (8 hr). 2 -ethoxyethanol was readily absorbed.
Skin absorption of 2 -ethoxyethanol:
| Compound | Permeability constant, cm/hr x 10^4 | Rate of absorption, mg/cm²/hr | Damage ratio | Approx. lag time, hr |
| 2 -ethoxyethanol | 8.42 | 0.796 +/-0.460 (n=11) | 2.74 +/-1.46 (n=10) | <1 |
The damage ratio is the ratio of skin permeability to tritiated water after contact with the test compound to that recorded before such
contact. Some slight degree of irreversible damage has been induced by the test substance but this is unlikely to have had a significant
effect on permeability (Control damage ratio values for water contact alone lay between 1.0 and 2.0).
Applicant's summary and conclusion
- Conclusions:
- In an in-vitro experiment the absorption of the test substance 2 -ethoxyethanol across isolated human abdominal epidermis was measured. Some slight degree of irreversible damage has been induced by the test substance but this is unlikely to have had a significant effect on permeability.
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