Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 233-113-0 | CAS number: 10035-10-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- A study for acute toxicity by the dermal route of gaseous HBr or hydrobromic acid is not justified as the substance is corrosive, and sufficient information is available for the inhalation route.
- Executive summary:
- According to the Annex VIII Standard Information Requirements for REACH,
.an acute toxicity test by the dermal route is required. A specific rule
for adaptation (Column 2) for the acute dermal test states that the study
(ies) do not need to be conducted if inhalation of the substance is
unlikely, skin contact during production is likely, and the
physicochemical and toxicological properties suggest a potential for a
significant rate of absorption through the skin.
Also in Annex VII, a specific rule for adaptation (Column 2) for acute oral toxicity in the 8.5 series states that the need for a second study by another route is based on potential route of human exposure. If there is only one route of exposure, information for only that route need be provided.
In case of release of hydrogen bromide (HBr) gas or a spill of liquid hydrogen bromide, exposure by inhalation is likely as the material would volatilize. Skin contact during production is not likely because of production in closed systems. Toxicological studies have shown that HBr gas and hydrobromic acid (the strong mineral acid formed by hydrogen bromide in water) are well known to cause burns to skin and eyes. This fact is reflected in the EU classification and labelling of HBr and hydrobromic acid as it is classified/labelled with the symbols “C” and “Xi” and the risk phrases “R35” and “R37”. As sufficient acute toxicity data by the inhalation route is available for classification, it is not scientifically justified to conduct this test by the dermal route.
Thus, exposure of mammalian species to HBr or hydrobromic acid by the dermal route would not generate meaningful data, and it is not necessary to conduct the acute dermal toxicity test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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