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Diss Factsheets
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EC number: 252-104-2 | CAS number: 34590-94-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- PROCEDURE
This test (also called inhalation risk test) was performed in principle as described in OECD Guideline 403.
It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at the temperature chosen for vapor generation (usually 20 °C).
Young adult laboratory rats were purchased from a breeder. In general, the source and strain of the animals were not documented.
Several groups of usually 3 rats per sex were exposed sequentially to the vapors, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for different time periods (e.g. 3 min, 10 min, 1, 3 or 7 or 8 hours). The exposure time not causing lethality was usually tested twice.
No analytical determination of the atmosphere concentrations was performed. The nominal concentration usually can be calculated as quotient of the amount of test substance weight loss during the exposure, which is given in the raw data, and the amount of air used during the exposure.
Group-wise documentation of clinical signs was performed over the 7- to 14-day study period. Body weight of groups was determined before the start of the study and at the end of the observation period in the surviving animals.
The clinical signs and findings were reported in summarized form.
The study allows for an estimate of the length of time required to cause severe toxic effects resulting from exposure to an atmosphere saturated with vapours of the test substance. The exposure time causing 50 % lethality (LT50) can be estimated from such a study as described for the LD50. Furthermore, using the nominal concentration, vapour pressure and LT50, in many cases a 4-hour LC50 can be estimated using Haber's law.
(Inhalation Risk Test (IRT) in the rat: method according to Smyth et al., Am.Ind.Hyg. Ass.J. 23, 1962) - GLP compliance:
- no
- Test type:
- other: Inhalation Risk Test (IRT)
Test material
- Reference substance name:
- (2-methoxymethylethoxy)propanol
- EC Number:
- 252-104-2
- EC Name:
- (2-methoxymethylethoxy)propanol
- Cas Number:
- 34590-94-8
- Molecular formula:
- C7H16O3
- IUPAC Name:
- 2-[(1-methoxypropan-2-yl)oxy]propan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Methoxypropoxypropanol
- Physical state: liquid
- Substance number: 78/187
- Vapour pressure (20°C): 0.4 Torr
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- TEST ATMOSPHERE
- mean concentration of TS: 1.66 mg/l (275 ppm) - Duration of exposure:
- 7 h
- No. of animals per sex per dose:
- 12 animals were used
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 275 ppm
- Exp. duration:
- 7 h
- Mortality:
- 0%
(no animal died after application of the TS and during the observation period) - Clinical signs:
- other: irritation of the mucosa: wiping of the snout, watery nose secretion, dyspnea, scrubby fur
- Gross pathology:
- no findings
Any other information on results incl. tables
No mortalities (0/12) after 7-hour exposure to an atmosphere enriched with the test substance vapour at 20°C.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Dipropylene glycol methyl ether is not acutely toxic via the inhalation route. Based on the LC0 > 275 ppm (1667 mg/m3) no classification is required according to EU criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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