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EC number: 232-160-4 | CAS number: 7789-38-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Review by a recognised source.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 001
- Reference Type:
- publication
- Title:
- Toxicity and carcinogenicity of potassium bromate--a new renal carcinogen.
- Author:
- Kurokawa Y; Maekawa A; Takahashi M; et al.
- Year:
- 1 990
- Bibliographic source:
- Environ Health Perspect 87:309-335, 1990. Cited in EPA 2001.
- Reference Type:
- publication
- Title:
- (1989) Renal changes induced by chronic oral administration of potassium bromate or ferric nitrilotriacetate in Wistar rats.
- Author:
- Nakano, K; Okada, S; Toyokuni, S; et al.
- Year:
- 1 989
- Bibliographic source:
- Jpn Arch Intern Med 36:41-47, 1989. Cited in EPA 1989.
Materials and methods
- Principles of method if other than guideline:
- A review of existing data.
The investigations were performed with potassium bromate. A read across to sodium bromate is justified as both substances dissociated in water and Na+ and K+ ions are naturally occurring species. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Potassium bromate.
- IUPAC Name:
- Potassium bromate.
- Reference substance name:
- Potassium bromate
- EC Number:
- 231-829-8
- EC Name:
- Potassium bromate
- Cas Number:
- 7758-01-2
- IUPAC Name:
- potassium bromate
- Reference substance name:
- Bromic acid, potassium salt
- IUPAC Name:
- Bromic acid, potassium salt
Constituent 1
Constituent 2
Constituent 3
Results and discussion
Results of examinations
- Details on results:
- The subchronic effects of bromate were evaluated by Kurokawa et al. (1990), who administered potassium bromate in water at concentrations of 0, 150, 300, 600, 1250, 2500, 5000, or 10000 ppm to groups of F344 rats (10/sex/group) for 13 weeks. Assuming average default drinking water consumption of 0.4 L/day and an average default body weight of 0.3 kg, the authors calculated doses corresponding to these concentrations as about 0, 16, 32, 63, 140, 270, 650, or 1080 mg BrO3-/kg and day. All animals exposed to >1250 ppm died within 7 weeks. Observed signs of toxicity included significant inhibition of body weight gain in males at 600 ppm or above and significant increases of serum parameters (glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, lactate dehydrogenase, alkaline phosphatase, blood urea nitrogen [BUN], Na+, and cholinesterase) in both sexes at 600 ppm. Serum potassium levels were significantly decreased. Droplets of various sizes and regenerative changes in the renal tubules were observed. This study identifies 63 mg BrO3-/kg/day as an adverse effect level, but insufficient data were provided to determine whether effects occurred at lower doses.
Nakano et al. (1989) exposed male Wistar rats to 0.04% potassium bromate in drinking water for up to 15 months. At an intake of 0.1 L/kg/day, this corresponds to a dose of about 30 mg BrO3-/kg/day. Body weight gain was markedly inhibited in the exposed animals. Histological examination of kidneys at 7–11 weeks revealed karyopyknotic foci (a necrotic change characterized by shrinking of the nucleus and condensation of the chromatin) in tubules of the inner medulla. Increased BUN was noted after 15 months, along with marked structural abnormalities of the cortical tubules. On the basis of the decreased body weight gain and renal effects, this study identified a lowest-observed-adverse-effect-level (LOAEL) of 30 mg BrO3-/kg.day, but did not identify a no-observed-adverse-effect-level (NOAEL).
Effect levels
open allclose all
- Dose descriptor:
- LOAEL
- Effect level:
- <= 63 mg/kg bw/day (nominal)
- Based on:
- other:
- Sex:
- male/female
- Basis for effect level:
- other: Result of a 13 weeks toxicity study with rats.
- Dose descriptor:
- LOAEL
- Effect level:
- 30 mg/kg bw/day (nominal)
- Based on:
- other: bromate (BrO3-)
- Sex:
- male
- Basis for effect level:
- other: From a 15 months toxicity study with rats.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- A 13 weeks toxicity study with rats was performed by dosing the animals with potassium bromate in the drinking water. The LOAEL was below 63 mg BrO3-/kg bw/day.
A 15 months toxicity study with male rats was performed by dosing the animals with potassium bromate in the drinking water. The LOAEL was 30 mg BrO3-/kg bw/day. - Executive summary:
A 13 weeks toxicity study with rats was performed by dosing the animals with potassium bromate in the drinking water. The LOAEL was below 63 mg BrO3-/kg bw/day.
A 15 months toxicity study with male rats was performed by dosing the animals with potassium bromate in the drinking water. The LOAEL was 30 mg BrO3-/kg bw/day.
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