Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 276-743-1 | CAS number: 72624-02-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985-09-05 to 1985-09-30
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP study to Guideline but insufficient information included in the report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Phenol, heptyl derivs.
- EC Number:
- 276-743-1
- EC Name:
- Phenol, heptyl derivs.
- Cas Number:
- 72624-02-3
- Molecular formula:
- C13H20O
- IUPAC Name:
- 4-(2-methylhexyl)phenol; 4-heptylphenol
- Details on test material:
- - Physical state: amber liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ace Animals, Inc., Boyertown, PA USA
- Age at study initiation: Not specified
- Weight at study initiation: 2.0 - 3.0 kg
- Fasting period before study: No
- Housing: In accordance with Guidance: DHEW No. 80-23
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum):ad libitm
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 60 - 75°F
- Humidity (%): 55±25%
- Air changes (per hr): Not specified
- Photoperiod (hrs dark / hrs light): 12 hour light/dark cycle
IN-LIFE DATES: From: 1985-09-05 To: 1985-09-19
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back
- % coverage: 10% of body surface
- Type of wrap if used: Large porous gauze patch wrapped with impervious material
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2.0 g/kg - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 per sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Frequently on first day of dosing and twice per day (morning and afternoon) on week days, once on weekends and holidays. Weights recorded on day of dosing, weekly thereafter and prior to sacrifice.
- Necropsy of survivors performed: yes/no
- Other examinations performed: clinical signs, body weight, gross necropsy
Results and discussion
- Preliminary study:
- Not performed
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There was one mortality, one female died at the day 12 observation period.
- Clinical signs:
- other: Males: Signs of necrosis and severe oedema were observed for 5/5 animals after unwrapping at 24 hours. Eschar was noted in 3/5 animals at 48 hours and for 2/5 animals at 72 hours. The eschar began to peel at 7 days in 3/5 animals, at 8 days in 1/5 animals
- Gross pathology:
- Males:
No gross abnormalities were noted for the animals necropsied at the conclusion of the 14 day observation period.
Females:
Diarrhea, signs of dehydration and no formal fecal material in the lower gastrointestinal tract were noted for the animal found dead at 12 days. No gross abnormalities were noted for the animals necropsied at the conclusion of the 14 day observation period. - Other findings:
- No measurable residual test material left on animals after the 24 hour contact period.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test article, when administered as received to male and female New Zealand White rabbits, had an acute dermal LD50 of greater than 2000 mg/kg bodyweight. In accordance with EU CLP Regulation (EC) No. 1272/2008, classification of this substance is not required for acute dermal toxicity.
- Executive summary:
Test Guidance
Acute dermal toxicity was performed in a similar manner to a method described in EPA OPP 81 -2
Method and Material
A single dose of 2 g/kg undiluted test material was applied to the shaved backs of ten New Zealand White rabbits (5 males and 5 females). The test material was covered with an occlusive dressing for a period of 24 hours. At the end of the exposure period, the treated area was wiped to remove any residual test material. The animals were observed for deaths or overt signs of toxicity daily for 14 days. The sites were also examined for evidence of primary irritation daily for 14 days. Individual bodyweights were recorded prior to application of the test material at the start of the study and on days 7 and 14. At the end of the observation period all animals were euthanized and subjected to gross necropsy.
Results
There was one mortality, one female died at the day 12 observation period.
Males: Signs of necrosis and severe oedema were observed for 5/5 animals after unwrapping at 24 hours. Eschar was noted in 3/5 animals at 48 hours and for 2/5 animals at 72 hours. The eschar began to peel at 7 days in 3/5 animals, at 8 days in 1/5 animals and at 9 days in 1/5 animals. Other than the above observations, all other animals appeared normal throughout the 14 day observation period. A loss of bodyweight was noted for 1/5 animals at 7 and 14 days. No gross abnormalities were noted for the animals necropsied at the conclusion of the 14 day observation period.
Females: Signs of necrosis and severe oedema were obsserved for 5/5 animals after unwrapping at 24 hours. Eschar was noted for 5/5 animals by 48 hours which began to peel in 4/5 animals at 8 days and in 1/5 animals at 10 days. No adverse syptoms (except loss of bodyweight) preceded the death of one animal on day 12. Other than the above observations, the remaining 4/5 animals appeared normal throughout the observation period. There was a loss of bodyweight at 7 days in the animal that died. Loss of bodyweight was noted for 2/5 animals at 7 days and for 1/5 of remaining animals at 14 days. Diarrhea, signs of dehydration and no formal fecal material in the lower gastrointestinal tract were noted for the animal found dead at 12 days. No gross abnormalities were noted for the animals necropsied at the conclusion of the 14 day observation period.
The dermal LD50 of the test material in male and female rabbits has been determined to be greater than 2000 mg/kg bw.
Conclusion
In accordance with EU CLP Regulation (EC) No. 1272/2008, classification of this substance is not required for acute dermal toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.