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Diss Factsheets
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EC number: 202-425-9 | CAS number: 95-50-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March to April 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Comparable to guideline study with acceptable restrictions (24h instead of 4h exposure (worst case); observation after 60min, 48h and 14 days was not conducted (scores of 24h were also assumed for 48h time point (worst case)); impervious instead of semi-occlusive patch was used; new calculation of scoring averages was necessary)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: ETAD guideline
- Deviations:
- yes
- Remarks:
- ; application only on intact skin
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- ; 24h instead of 4h exposure (worst case); observation after 60min, 48h and 14 days was not conducted (scores of 24h were also assumed for 48h time point (worst case)); impervious instead of semi-occlusive patch was used; new calculation of
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,2-dichlorobenzene
- EC Number:
- 202-425-9
- EC Name:
- 1,2-dichlorobenzene
- Cas Number:
- 95-50-1
- Molecular formula:
- C6H4Cl2
- IUPAC Name:
- 1,2-dichlorobenzene
- Details on test material:
- - Analytical purity: 1,2-dichlorobenzene, chemically pure (no further data)
Constituent 1
Test animals
- Species:
- rabbit
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hacking & Churchill, Huntingdom, Great Britain
- Weight at study initiation: 3-4 kg
- Housing: separately in standard cages
- Diet (e.g. ad libitum): Z 222 from Hönig, Verden/Aller, Germany ad libitum
- Water (e.g. ad libitum): ad libitum
Test system
- Type of coverage:
- other: surgical gauze patch wrapped with an impervious material
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: not applicable
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 24h
- Observation period:
- timepoints: 24h, 72h and 7 days
- Number of animals:
- six
- Details on study design:
- TEST SITE
- Area of exposure: approximately 6 cm2
- Type of wrap if used: surgical gauze patch wrapped with an impervious material
SCORING SYSTEM:
according to Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24h-72h
- Score:
- 1.56
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24-72h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Other effects:
- none
Any other information on results incl. tables
Table: Evaluation results of skin reactions after 1,2-dichlorobenzene administration to rabbits
Animal No. | Symptoms | Time points for skin evaluation | |||
24 hours | 48 hours* | 72 hours | 7 days | ||
224 | Erythema | 2 | 2 | 1 | 0 |
224 | Oedema | 2 | 2 | 0 | 0 |
229 | Erythema | 1 | 1 | 0 | 0 |
229 | Oedema | 1 | 1 | 0 | 0 |
230 | Erythema | 2 | 2 | 1 | 1 |
230 | Oedema | 1 | 1 | 1 | 0 |
231 | Erythema | 2 | 2 | 1 | 1 |
231 | Oedema | 1 | 1 | 1 | 0 |
232 | Erythema | 2 | 2 | 2 | 1 |
232 | Oedema | 1 | 1 | 1 | 0 |
233 | Erythema | 2 | 2 | 1 | 1 |
233 | Oedema | 1 | 1 | 1 | 0 |
Average (24h,48h,72h) | Erythema | 1.56 | -- | ||
Average (24h,48h,72h) | Oedema | 1 | -- |
* : not observed; same scores assumed as for 24h time point (worst case)
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant)
- Conclusions:
- According to the non-reversible irritation at the end of the observation period of 7 days, 1,2-dichlorobenzene should be classified and labelled as Category 2 (irritant) (EU-GHS).
- Executive summary:
Thyssen, 1979 (Bayer study report)
An acute dermal irritation/corrosion study was conducted according to ETAD guideline (deviation: application only on intact skin) and similar to OECD Guideline 404. According to the OECD guideline, the study was performed with the following deviations: 24h exposure period instead of 4h exposure period (worst case); observation after 60min, 48h and 14 days was not conducted (scores of 24h were also assumed for 48h time point (worst case)); impervious instead of semi-occlusive patch was used.
Six New Zealand White rabbits were exposed to 0.5 mL 1,2-dichlorobenzene for 24 hours. Observation time points were 24h, 72h and 7 days after removal of the patch.
The mean erythema score between 24h and 72h was 1.56. Irritation was not fully reversible within 7 days. For the mean oedema score between 24h and 72h, a value of 1 was calculated. The effects were fully reversible within 7 days.
According to the non-reversible irritation at the end of the observation period of 7 days, 1,2-dichlorobenzene should be classified and labelled as Category 2 (irritant) (EU-GHS).
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