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Diss Factsheets
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EC number: 209-143-5 | CAS number: 556-88-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu./o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- other: Collection of data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: not reported
- Principles of method if other than guideline:
- Collection of data
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Test substance supplier not specified
- No.:
- #1
- pKa:
- 12
- Remarks on result:
- other: No temperature stated
- Conclusions:
- Nitroguaninide is both a week acid with a pKa of 12.8, and a weak base with a low pKa of -1.3. Nitroguanidine therefore exists predominantly as a neutral species under environmental conditions.
- Executive summary:
Nitroguaninide is both a week acid with a pKa of 12.8, and a weak base with a low pKa of -1.3. Nitroguanidine therefore exists predominantly as a neutral species under environmental conditions.
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- GLP compliance:
- no
- Specific details on test material used for the study:
- Lot/batch No.: 931601
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 1.41
- Temp.:
- 20 °C
- No.:
- #2
- pKa:
- 1.55
- Temp.:
- 20 °C
- No.:
- #3
- pKa:
- 1.33
- Temp.:
- 20 °C
- No.:
- #4
- pKa:
- 1.38
- Temp.:
- 20 °C
- No.:
- #5
- pKa:
- 1
- Temp.:
- 20 °C
- No.:
- #6
- pKa:
- 1.41
- Temp.:
- 20 °C
- No.:
- #7
- pKa:
- 1.41
- Temp.:
- 20 °C
- No.:
- #8
- Temp.:
- 20 °C
- Remarks on result:
- other: Value was not included in the calculation due to the low measured conductivity and the appropriately resulting measuring inaccuracy.
- No.:
- #9
- Temp.:
- 20 °C
- Remarks on result:
- other: Value was not included in the calculation due to the low measured conductivity and the appropriately resulting measuring inaccuracy.
- Conclusions:
- The dissociation constant (KD) was determined to be 0.0370 mol dm-3. The pKD-value is 1.43.
- Executive summary:
The study was conducted according OECD Guideline 112 using the conductometric method. The dissociation constant (KD) was determined to be 0.0370 mol dm-3. The pKD-value is 1.43.
Referenceopen allclose all
Nitroguaninide is both a week acid with a pKa of 12.8, and a weak base with a low pKa of -1.3. Nitroguanidine therefore exists predominantly as a neutral species under environmental conditions.
The graphs for molar conductivity and the limit of conductivity are shown in the attached background material.
The limit of conductivity is determined to be 0.52 Ω-1cm² mol-1
Description of key information
The study was conducted according to OECD Guideline 112 using the conductometric method.
The dissociation constant (KD) was determined to be 0.0370 mol dm-3. The pKD-value is 1.43.
Additional information is provided within the supporting study from a collection of data: Nitroguaninide is both a week acid with a pKa of 12.8, and a weak base with a low pKa of -1.3. Nitroguanidine therefore exists predominantly as a neutral species under environmental conditions.
Key value for chemical safety assessment
- pKa at 20°C:
- 1.43
Additional information
The study was conducted according the the appropriate OECD Guideline. The collection of data does not inlcude temperature information. Therefore the study result is used.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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