Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-626-7 | CAS number: 123-42-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without detailed documentation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- -body weights not reported, and gross pathologic examinations were conducted but no data was presented in report
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-hydroxy-4-methylpentan-2-one
- EC Number:
- 204-626-7
- EC Name:
- 4-hydroxy-4-methylpentan-2-one
- Cas Number:
- 123-42-2
- Molecular formula:
- C6H12O2
- IUPAC Name:
- 4-hydroxy-4-methylpentan-2-one
- Details on test material:
- - Name of test material (as cited in study report): diacetone alcohol (DAA)
- Physical state: Stated in the report as a "widely used solvent"
- Analytical purity: Not reported
- Lot/batch No.: Reference PER 47657/2
- Expiration date of the lot/batch: Not reported
- Stability under test conditions: Not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Shell Toxicology Laboraotry (Tunstall) Breeding Unit
- Age at study initiation: Approximately 10 weeks
- Weight at study initiation: Not reported
- Fasting period before study: Not reported
- Housing: Four animals/sex were housed in each cage.
- Diet (e.g. ad libitum): Rat food (PRD, Labsure Animal Foods Ltd.), ad libitum; however, during the 24 hr exposure period, food was withheld
- Water (e.g. ad libitum): Filtered but untreated water from the public supply, provided by means of water bottles refilled every other day
- Acclimation period: Not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): room temperature, 22 ± 2
- Humidity (%): 55 ± 5
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal
- % coverage: Not reported
- Type of wrap if used: The test substance was covered with a piece of aluminium foil and held in place by a double overwrap of waterproof adhesive tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The foil and plaster dressing was carefully removed and the skin was washed with warm dilute detergent solution and then dried.
- Time after start of exposure: at the end of the 24 hr exposure period
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2 mL/kg body weight
- Concentration (if solution): undiluted
- Constant volume or concentration used: yes - Duration of exposure:
- 24 hours
- Doses:
- 2 mL/kg body weight (1875 mg/kg body weight)
- No. of animals per sex per dose:
- 6 animals/sex
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 or 21 days
- Frequency of observations and weighing: Body weights were recorded initially, Day 7, and on Day 14.
- Necropsy of survivors performed: yes
- Other examinations performed: Animals were observed for signs of toxicity over 14 or 21 days.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 1 875 mg/kg bw
- Mortality:
- The application of undiluted chemical for 24 hours to groups of 6 male and 6 female rats did not result in any mortalities at a dose level of 2 mL/kg body weight, the largest volume that could be applied to the skin.
- Clinical signs:
- other: Rats showed no toxic signs.
- Gross pathology:
- Results were not reported.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- The acute (24 h) percutaneous LD50 of the test material in rats was greater than 2 mL/kg body weight, the largest volume that could be applied to the skin (equivalent to greater than 1875 mg/kg body weight).
- Executive summary:
The potential acute dermal toxicity of diacetone alcohol was assessed in Wistar rats in a study similar in methodology to OECD Guidelines for the Testing of Chemicals No. 402 (Cassidy and Blair, 1978). Undiluted diacetone alcohol was applied for 24 hours to 6 male and 6 female rats at 2 mL/kg body weight (equivalent to 1875 mg/kg body weight) for 24 hours. The test substance was applied to the shaved dorsal skin of the animals andcovered with a piece of aluminium foil held in place by a double overwrap of waterproof adhesive tape. After 24 hours, the foil and plastic dressing were removed, and the skin was washed with warm dilute detergent and dried. The animals were observed for signs of toxicity for 14 or 21 days and necropsy was performed. There were no reactions or clinical signs of toxicity, and the dermal LD0 of diacetone alcohol was reported to be greater than 2 mL/kg body weight (equivalent to 1875 mg/kg body weight).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.