Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-944-8 | CAS number: 89-83-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: no guideline study, few experimental data
Data source
Reference
- Reference Type:
- publication
- Title:
- Essential oil of Lippia grata: Pharmacological effects and main constituents
- Author:
- Viana GSB, Matos FF, Araujo WL, Matos FJA, Craveiro AA
- Year:
- 1 981
- Bibliographic source:
- Quart J Crude Drug Res 19, 1-10
Materials and methods
- Principles of method if other than guideline:
- Acute toxicity in mice: Thymol was given by i.p. injection to 6 groups of 3-6 adult Swiss mice each (sex at random). The doses ranged from 33.3 to 223 mg/kg body weight for commercial tymol. Mortality and sequential effects during 3 days were determined.
- GLP compliance:
- no
Test material
- Reference substance name:
- Thymol
- EC Number:
- 201-944-8
- EC Name:
- Thymol
- Cas Number:
- 89-83-8
- Molecular formula:
- C10H14O
- IUPAC Name:
- 5-methyl-2-(propan-2-yl)phenol
Constituent 1
- Specific details on test material used for the study:
- Thymol (no data on purity), purchased from Merck & Co., Germany
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Doses:
- 33.3, 50.0, 73.3, 110.0, 166.6, 233.3 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 110 other: mg/kg bw
- Remarks on result:
- other: 3 days LD50
Any other information on results incl. tables
Dose/kg Death Sequential Effects
33.3 mg 0/3 no effect
50.0 mg 0/3 slight ataxia
73.3 mg 1/3 ataxia, decreased spontanous motor
activity, death
110.0 mg 3/3 ataxia, decreased spontaneous motor
activity, somnolence, death
166.6 mg 3/3 ataxia, decreased spontaneous motor
activity, somnolence, death
233.3 mg 3/3 ataxia, decreased spontaneous motor
activity, somnolence, death
The animals were observed for a period of 3 days
Applicant's summary and conclusion
- Executive summary:
Acute toxicity in mice: Thymol was given by i.p. injection to 6 groups of 3-6 adult Swiss mice each (sex at random). The doses ranged from 33.3 to 223 mg/kg body weight for commercial tymol. Mortality and sequential effects during 3 days were determined.
The approximate 3 days LD50 was 110 mg/kg bw for thymol
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.