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EC number: 433-360-6 | CAS number: 34036-80-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000-02-10 to 2000-02-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test method according to with EEC method B5, OECD guidelin 405 with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2400 (Acute Eye Irritation)
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 433-360-6
- EC Name:
- -
- Cas Number:
- 34036-80-1
- Molecular formula:
- C18H29N3O3Si
- IUPAC Name:
- 6-{[(butan-2-ylidene)amino]oxy}-3,9-dimethyl-6-phenyl-5,7-dioxa-4,8-diaza-6-silaundeca-3,8-diene
- Reference substance name:
- 2-butanone-O,O',O''- (phenylsilylidyne)trioxime
- IUPAC Name:
- 2-butanone-O,O',O''- (phenylsilylidyne)trioxime
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report):Phenyltris-(methylethylketoximino)silane
- Physical state: Clear liquid
- Lot no.: M-350B
- Expire time: 1 June 2000
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Ltd, Bicester, Oxon, England
- Initial weight: 2.1 to 3.2 kg
- Age at test initiation: At least 10 weeks of age
- Housing: Individually in metal cages with perforated floors.
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 21 days
ENVIRONMENTAL CONDITIONS:
-Temperature: 23 to 24°C
- Humidity: <20 to 35%
- Photoperiod: 12 hours of artificial light (0600 - 1800 hours GMT) in each 24 hours period.
In-life dates: from: Feb 10, 2000; To: Feb 14, 2000.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 ml of the test substance placed in the lower everted lid of one eye of each animal. The eyelids were then gently held together for one second before releasing.
- Duration of treatment / exposure:
- Single exposure.
- Observation period (in vivo):
- 1 hour and 1, 2 and 3 days after instillation. Additional observations were made for one animal four days after instillation.
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- SCORING SYSTEM: According to guidelines.
CORNEAL OPACITY: Degree of density (area most dense taken for reading)
- No ulceration or opacity: 0
- Scattered or diffuse areas of opacity (other than slight dulling of normal lustre), details of iris clearly visible: 1
- Easily discernible translucent area, details of iris slightly obscured: 2
- Nacreous area, no details of iris visible, size of pupil barely discernible: 3
- Opaque cornea, iris not discernible through the opacity: 4
IRIS:
- Normal: 0
- Markedly deepened rugae, congestion, swelling, moderate circumcorneal hyperaemia, or injection, any of these or combination of any thereof, iris still reacting to light (sluggish reaction is positive): 1
- No reaction to light, haemorrhage, gross destruction (any or all of these): 2
CONJUNCTIVAE: Redness (refers to palpebral and bulbar conjunctivae)
- Blood vessels normal: 0
- Some blood vessels definitely hyperaemic (injected): 1
- Diffuse, crimson colour, individual vessels not easily discernible: 2
- Diffuse beefy red: 3
EDEMA: Lids and/or nictitating membranes
- No swelling: 0
- Slight swelling (includes nictitating membranes): 1
- Obvious swelling with partial eversion of lids: 2
- Swelling with lids about half-closed: 3
- Swelling with lids more than half-closed: 4
TOOL USED TO ASSESS SCORE: handheld light
OTHER OBSERVATIONS: Clinical signes: All animals were observed daily for signs of ill health or toxicity.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: mean 24-72h
- Score:
- 0.7
- Max. score:
- 3
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: mean 24-72h
- Score:
- 0.7
- Max. score:
- 3
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: mean 24-72h
- Score:
- 1.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 4 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: mean 24-72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: mean 24-72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- other: mean 24-72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: mean 24-72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- other: mean 24-72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- other: mean 24-72h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: mean 24-72h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other: mean 24-72h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- other: mean 24-72h
- Score:
- 0
- Max. score:
- 2
- Irritant / corrosive response data:
- Dulling of the cornea was evident one hour after dosing only in one of the three treated animals No iridial inflammation was observed in any animal throughout the observation period. Conjunctival inflammation up to Grade 2 in intensity was evident in all three animals one hour after instillation, with the level of response decreasing over the following days before resolving in all instances between three and four days of instillation.
- Other effects:
- There were no signs of toxicity or ill health in any rabbit during the observation period.
Any other information on results incl. tables
Oculat reactions:
Rabbit |
Region of the eye |
One hour |
Day after installation |
||||
1 |
2 |
3 |
4 |
||||
100 Female |
Cornea |
Density |
D |
0 |
0 |
0 |
0 |
Area |
4 |
0 |
0 |
0 |
0 |
||
Iris |
0 |
0 |
0 |
0 |
0 |
||
Conjunctiva |
Redness |
2 |
2 |
1 |
1 |
0 |
|
Chemosis |
2 |
0 |
0 |
0 |
0 |
||
95 Female |
Cornea |
Density |
0 |
0 |
0 |
0 |
- |
Area |
0 |
0 |
0 |
0 |
- |
||
Iris |
0 |
0 |
0 |
0 |
- |
||
Conjunctiva |
Redness |
2 |
1 |
1 |
0 |
- |
|
Chemosis |
2 |
0 |
0 |
0 |
- |
||
96 Female |
Cornea |
Density |
0 |
0 |
0 |
0 |
- |
Area |
0 |
0 |
0 |
0 |
- |
||
Iris |
0 |
0 |
0 |
0 |
- |
||
Conjunctiva |
Redness |
2 |
1 |
1 |
0 |
- |
|
Chemosis |
2 |
0 |
0 |
0 |
- |
D: Dulling of the cornea
-: Not applicable
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In accordance with CLP Regulation, the test substance is not classified as irritating to the eyes.
- Executive summary:
An eye irritation study was performed with thest item according to EEC Method B5 and OECD Guideline 405. Three rabbits were each administered a single ocular dose of a volume of 0.1 ml of the test substance and observed for up to four days after instillation. Test item elicited dulling of the cornea (evident one hour after dosing only in one of the three treated animals), no iridial inflammation and transient conjunctival inflammation up to Grade 2 in intensity evident in all three animals one hour after instillation, with the level of response decreasing over the following days before resolving in all instances between three and four days of instillation. The mean 24 -72 hours conjunctivae redness scores were 0.7, 0.7 and 1.3 for each animal. On the basis of these results and in accordance with CLP Regulation, the substance is not classified as irritating to the eyes.
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