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Diss Factsheets
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EC number: 205-410-5 | CAS number: 140-29-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2a: Guideline study without detailed documentation
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- other: Peer-reviewed database
- Title:
- Biodegradation and bioconcentration of existing chemical substances under the chemical substances control law
- Author:
- MITI
- Year:
- 1 981
- Bibliographic source:
- http://www.safe.nite.go.jp/english/sougou/view/ComprehensiveInfoDisplay_en.faces, CAS n° 140-29-4
- Reference Type:
- other: Peer-reviewed database
- Title:
- Data bank of environmental properties of chemicals
- Author:
- Kemikaali
- Year:
- 2 010
- Bibliographic source:
- http://wwwp.ymparisto.fi/scripts/Kemrek/Kemrek.asp, CAS n° 140-29-4, Finnish Environment Insitute
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Deviations:
- yes
- Remarks:
- 2 weeks instead of 28 days
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenylacetonitrile
- EC Number:
- 205-410-5
- EC Name:
- Phenylacetonitrile
- Cas Number:
- 140-29-4
- Molecular formula:
- C8H7N
- IUPAC Name:
- 2-phenylacetonitrile
- Details on test material:
- No data
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No data
Study design
- Oxygen conditions:
- not specified
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Concentration of sludge: 30 ppm
No further data - Duration of test (contact time):
- 2 wk
Initial test substance concentration
- Initial conc.:
- 100 other: ppm
Parameter followed for biodegradation estimationopen allclose all
- Parameter followed for biodegradation estimation:
- O2 consumption
- Parameter followed for biodegradation estimation:
- TOC removal
- Details on study design:
- No data
Results and discussion
- Preliminary study:
- No data
- Test performance:
- No data
% Degradationopen allclose all
- Parameter:
- % degradation (O2 consumption)
- Value:
- 77
- Remarks on result:
- other: Indirect analysis
- Parameter:
- % degradation (TOC removal)
- Value:
- 96
- Remarks on result:
- other: Direct analysis
- Parameter:
- % degradation (O2 consumption)
- Value:
- 100
- Remarks on result:
- other: value determined by converting the amount of the product phenylacetic acid to the amount of phenylacetonitrile
- Details on results:
- No further data
BOD5 / COD results
- Results with reference substance:
- No data
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Under the test conditions, according to indirect analysis 77% (BOD) and according to direct analysis 96% (TOC) and 100% (value determined by converting the amount of the product phenylacetic acid to the amount of phenylacetonitrile) of phenylacetonitrile was degradated after 2 weeks in a OECD guidline 301C test. Thus the substance should be considered as readily biodegradable according to the EC regulation n°1272/2008 and the former 67/548/EC regulation.
- Executive summary:
The authors tested the biodegradability of phenylacetonitrile (CAS n° 140-29-4) according to the OECD guideline 301C. They tested 100 ppm of the substance in a 30 ppm concentration of activated sludge using standard equipment. After two weeks 77% of the test substance was biodegradated according to indirect analysis (BOD) and according to direct analysis 96% (TOC) and 100% (value determined by converting the amount of the product phenylacetic acid to the amount of phenylacetonitrile). Thus phenylacetonitrile should be considered as readily biodegradable.
No data was available on the GLP procedure during this test. Few details are available, as a result the validity criteria could not be checked. However considering that the authors followed the OECD guideline 301C and reported the main information, the study should be considered as reliable with restrictions ( Guideline study without detailed documentation).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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