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EC number: 484-460-1 | CAS number: 37859-55-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
PHYSICO-CHEMICAL PROPERTIES
- Vapour pressure: 0.077 mm Hg
- Water solubility: Cannot be determined due to limited stability of test substance in aqueous solutions (half life time < 4 minutes)
- Stability of test material at room temperature: Stable
OTHER PROPERTIES (if relevant for this endpoint) Quick hydrolysis of test substance expected - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling methods for the volatile compounds, if any: None
- Sampling intervals/times for pH measurements: Four minutes and one hour after preparation a sample was taken from the upper organic phase and analysed.
- Other observation, if any (e.g.: precipitation, color change etc.):None - Buffers:
- Acetate buffer pH 4 : Solution of 16.6% 0.05 M Sodium Acetate and 83.4% 0.05 M Acetic Acid
Phosphate buffer pH 7: Solution of 0.05 M Potassium Dihydrogenphosphate adjusted to pH 7 using 1 N Sodium Hydroxide
Borate buffer pH 9: Solution of 0.05 M Boric Acid and 0.05 M Potassium Chloride adjusted to pH 9 using 1 N Sodium Hydroxide - Details on test conditions:
- TEST SYSTEM
- Sterilisation method: None
- Measures taken to avoid photolytic effects: During the test, the test substance and test substance solutions were protected from light.
- Measures to exclude oxygen: During the test, the test substance and test substance solutions were kept under nitrogen.
- If no traps were used, is the test system closed/open Open
- Is there any indication of the test material adsorbing to the walls of the test apparatus? No
TEST MEDIUM
- Kind and purity of water: Tap water purified by a Milli-Q water purification system
- Preparation of test medium: 5 ml of test substance was mixed with 10 and 25 ml of each buffer in a glass vessel. Each vessel was inverted 10 times by hand and the phases were allowed to separate. Four minutes and 1 hour after preparation, a sample was taken from the upper organic phase and analysed. - Duration:
- 4 min
- pH:
- 4
- Initial conc. measured:
- 10 other: ml
- Duration:
- 4 min
- pH:
- 7
- Initial conc. measured:
- 10 other: ml
- Duration:
- 4 min
- pH:
- 9
- Initial conc. measured:
- 10 other: ml
- Duration:
- 1 h
- pH:
- 4
- Initial conc. measured:
- 25 other: ml
- Duration:
- 1 h
- pH:
- 7
- Initial conc. measured:
- 25 other: ml
- Duration:
- 1 h
- pH:
- 9
- Initial conc. measured:
- 25 other: ml
- Number of replicates:
- Total of 6:
3- 10 ml volume buffer solutions at pH 4, pH 7, pH 9
3- 25 ml volume buffer solutions at pH 4, pH 7, pH 9 - Positive controls:
- yes
- Remarks:
- untreated test substance
- Negative controls:
- no
- Statistical methods:
- The peak area of the major components with a retention time between 5 and 5.5 minutes was used as response in the calculations.
Degree of hydrolysis and relative concentration (%) calculated for each volume and pH. - Preliminary study:
- Quick hydrolysis of OS1600 was expected. To confirm this, the above-explained test was conducted.
- Test performance:
- All results show a quick reaction of test substance with buffer. When using 10 ml buffer, hydrolysis rate is lower than when using 25 ml buffer. From this it is concluded that 10 ml buffer is limiting the reaction rate.
When using 25 ml buffer solution pH4, pH 7, pH 9, a > 50% decrease concentration was observed after 4 minutes which demonstrates that the half-life time of the test substance is < 4 minutes at room temperature. - Transformation products:
- no
- Details on hydrolysis and appearance of transformation product(s):
- - Other: Quick hydrolysis of test substance was expected.
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- < 4 min
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- < 4 min
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- < 4 min
- Details on results:
- TEST CONDITIONS
- pH, sterility, temperature, and other experimental conditions maintained throughout the study: Yes
- Anomalies or problems encountered (if yes): No
MAJOR TRANSFORMATION PRODUCTS
At pH5:None
At pH7:None
At pH9:None
MINOR TRANSFORMATION PRODUCTS
Maximum concentrations in % of the applied amount
- at pH5:None
- at pH7:None
- at pH9:None
MINERALISATION (distinguish between dark and irradiated samples)
- % of applied radioactivity present as CO2 at end of study: None
INDICATION OF UNSTABLE TRANSFORMATION PRODUCTS:
VOLATILIZATION (at end of study)
- Evolved CO2 in % of the applied: .. at pH 5, .. at pH 7, .. at pH 9
- Total volatile organics in % of the applied: .. at pH 5, .. at pH 7, .. at pH 9
UNIDENTIFIED RADIOACTIVITY (at end of study)
- at pH4:None
- at pH7:None
- at pH9:None
PATHWAYS OF HYDROLYSIS
- Description of pathwayS:Not applicable
- Figures of chemical structures attached: No
SUPPLEMENTARY EXPERIMENT (if any): RESULTS: None - Validity criteria fulfilled:
- yes
- Conclusions:
- The half-life time of the test substance at room temperature were determined to be < 4 minutes at pH 4, 7 and 9.
According to the guideline, the test susbstance is considered hydrolytically instable and no further tests are required. - Executive summary:
The hydrolysis test was performed in accordance with OECD Guideline 111. Test substance was mixed with acetate buffer pH4, phosphate buffer pH 7 and borate buffer pH 9 in a glass vessel at room temperature and protected from light. Each vessel was inverted 10 times by hand and the phases were allowed to separate. Four minutes and 1 hour after preparation, a sample was taken from the upper organic phase and analysed. Chromatograms of the pretreated samples were compared with a chromatogram of untreated test substance. All results show a quick reaction of test substance with buffer. When using 10 ml buffer, hydrolysis rate is lower than when using 25 ml buffer. From this it is concluded that 10 ml buffer is limiting the reaction rate. When using 25 ml buffer solution pH4, pH 7, pH 9, a > 50% decrease concentration was observed after 4 minutes which demonstrates that the half-life time of the test substance is < 4 minutes at room temperature. The half-life of test item at pH 4, 7 and 9 was therefore determined to be < 4 minutes.
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Conducted with the main hydrolysis product= MPKO.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- The test substance was spiked to each of the buffer solutions at a nominal concentration of approximately 50 mg/L using a spike solution in water. for the test at pH 4, the peak areas of the test substance were determined immediately after preparation (t = 0) and at several sampling points after t = 0. The pH of the test samples was determined at the beginning and the end of the test. For the test at pH 7, the samples were prepared and placed in water baths at the end of the working day. The pH of the test samples was determined at the beginning and the end of the test.
- Buffers:
- Buffers: Acetate buffer pH 4: solution of 16.6 % 0.05 M sodium acetate and 83.4% 0.05 M acetic acid Phosphate buffer pH 7: solution of 0.05 M potassium di-hydrogenphosphate adjusted to pH 7 using 1 N sodium hydroxide Borate buffer pH 9: solution of 0.05 M boric acid and 0.05 M potassium chloride ajusted to pH 9 using 1 N sodium hydroxide
- Duration:
- 120 h
- pH:
- 7
- Duration:
- 120 h
- pH:
- 4
- Preliminary study:
- At pH 9, a decrease in concentration < 10% was observed after 120 hours. It demonstrate that the half-life time of the substance at 25 ºC > 1 year. According to the guideline, no further tests were required. At pH 4 and pH 7, a decrease in concentration > 10% after 120 hours was observed, and the main test was required. In order to determined reaction rate at 50 ºC, additional samples were taken at t= 261, 264 and 268 hours. After 268 hours of testing at 50 ºC, the relative concentration was still above 50%.
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Details on results:
- At the end of the tests, concentrations became stable at 50-60% of the initial concentration. This shows that equilibrium if formed and that this is not hydrolysis. The tes substance was determined to be hydrolytically stable (i.e. half-life time of > 1 year at 35 ºC) at pH 4, 7 and 9.
- Validity criteria fulfilled:
- yes
- Conclusions:
- MPKO is therefore considered hydrolytically stable (i.e. half-life time of > 1 year at 25°C) at pH 4, pH 7 and pH 9.
- Executive summary:
The hydrolysis test was performed in accordance with OECD Guideline 111 and EU Method C.7. In all tests performed, a decrease in concentration was observed. At the end of the main tests, concentrations became stable at 50 -60% of the initial concentration. This indicates that equilibrium is formed and that this is not hydrolysis. MPKO is therefore considered hydrolytically stable (i.e. half-life time of > 1 year at 25°C) at pH 4, pH 7 and pH 9.
Referenceopen allclose all
All results show a quick reaction of test substance with buffer. When using 10 ml buffer, hydrolysis rate is lower than when using 25 ml buffer. From this it is concluded that 10 ml buffer is limiting the reaction rate. When using 25 ml buffer solution pH4, pH 7, pH 9, a > 50% decrease concentration was observed after 4 minutes which demonstrates that the half-life time of the test substance is < 4 minutes at room temperature.
Description of key information
The half-life time of the test substance at room temperature were determined to be < 4 minutes at pH 4, 7 and 9. A hydrolysis test was also performed on MPKO, the hydrolytic product of OS1600. MPKO was considered to be hydrolytically stable (i.e. half-life time of > 1 year at 25°C) at pH 4, pH 7 and pH 9.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 4 min
- at the temperature of:
- 20 °C
Additional information
Key study: The hydrolysis test was performed in accordance with OECD Guideline 111 (GLP study). The half-life of test item at pH 4, 7 and 9 and room temperature was < 4 minutes, and therefore, the substance was determined to be hydrolytically instable.
Supporting study: The hydrolysis test was performed with the analogue substance MPKO in accordance with OECD Guideline 111 (GLP study). In all tests performed, a decrease in concentration was observed. At the end of the main tests, concentrations became stable at 50 -60% of the initial concentration. This indicates that equilibrium is formed and that this is not hydrolysis. MPKO is therefore considered hydrolytically stable (i.e. half-life time of > 1 year at 25°C) at pH 4, pH 7 and pH 9.
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