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Diss Factsheets
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EC number: 232-260-8 | CAS number: 7803-51-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Deficiencies: any identifiable toxic effect could be attributed to residus of undecomposed aluminium phosphinde, phosphine, reaction products formed with the food.
Data source
Reference
- Reference Type:
- publication
- Title:
- Chronic ingestion by rats of standard diet treated with aluminium phosphide
- Author:
- Hackenberg U.
- Year:
- 1 972
- Bibliographic source:
- Toxicol. appl. Pharmacol., 23: 147-158
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 453 (Combined Chronic Toxicity / Carcinogenicity Studies)
- Deviations:
- yes
- Remarks:
- Only one dose with important variation and 30 rats per dose.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Preparation of fumigation
- IUPAC Name:
- Preparation of fumigation
- Details on test material:
- Diet fumigated with phastoxin. After fumigation, the diet was tumbled for 2 hours to yield a constant mixing effect. The diet was then aerated for an hour period.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 2 years
- Frequency of treatment:
- The animals had continuous access to the diet.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.996 mg/kg diet
Basis:
other: mean phosphine analytic concentration in feed
- No. of animals per sex per dose:
- 30 rats per sex
- Control animals:
- yes, concurrent no treatment
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 0.996 mg/kg diet
- Based on:
- act. ingr.
- Sex:
- male/female
- Basis for effect level:
- other: Levels of phosphine remaining in the treated diets ranged from 0.377 mg/kg diet to 7.50 mg/kg diet.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- No effects dose level for rats fed with diet fumigated over a 2-year period wasobserved.
A statistically insignificant tendency for test females to gain weight faster than their control counterparts was found. There were no other differences between controls and treated rats in hemoglobin content, hematocrit, differential white blood cell count, glucose levels, SGPT, serum urea, prothrombin time, organ weights, or tissue histopathology. Survival rates and tumor incidences were similar between controls and experimental animals.
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