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EC number: 244-344-1 | CAS number: 21351-79-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-05-31 to 1994-06-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- JAPAN: Guidelines for Screening Mutagenicity Testing Of Chemicals
- Version / remarks:
- dated September 1, 1988
- Deviations:
- no
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Caesium hydroxide
- EC Number:
- 244-344-1
- EC Name:
- Caesium hydroxide
- Cas Number:
- 21351-79-1
- Molecular formula:
- CsHO
- IUPAC Name:
- caesium hydroxide
- Reference substance name:
- Cesium hydroxide
- IUPAC Name:
- Cesium hydroxide
- Test material form:
- solid: crystalline
Constituent 1
Constituent 2
Method
- Target gene:
- histidine operon
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- E. coli WP2 uvr A
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- Rat liver S9 mix (phenobarbital/5,6-benzoflavon induced)
- Test concentrations with justification for top dose:
- 313, 625, 1250, 2500 and 5000 µg/plate
- Vehicle / solvent:
- - Vehicle used: distilled water
- Justification for choice of solvent/vehicle: Good solubility in water.
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: Without S9-mix: 2-(2-Furyl)-3-(5-nitro-2-fury)acrylamide (TA 100, TA98, WP2 uvrA), Sodium azide (TA1535), 2-methoxy-6-chloro-9-[3-(2-chloroethyl)-aminoprpylamino]acridin (TA1537); With S9 mix: 2-Aminoanthracene (all strains)
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: preincubation
DURATION
- Preincubation period: 20 min at 37°C
- Exposure duration: 48 h at 37°C
NUMBER OF REPLICATIONS: 2
NUMBER OF INDIVIDUAL EXPERIMENTS: 1
DETERMINATION OF CYTOTOXICITY
- Method: relative total growth - Evaluation criteria:
- The test substance is judged to be positive, when the number of revertant colonies is more than twice of the negative control, and the dose relationship and the reproducibility are obtained.
- Statistics:
- no statistical analysis
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Species / strain:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- The results showed that the number of revertant colonies was less than twice of the negative control for all strains at any dose level with or wothout metabolic activation. The groth inhibition was observed in all strains at 5000 µg/plate. The positive controls showed a distinct increase of revertant colonies, and the positive controls and the negative controls were within a range of the background data of the laboratory. There were no fluctuations wich might have affected the test results because the sterility test confirmed the absence of micro organisms.
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Cesium hydroxide was judged to have no reverse mutagenic potenial in Ames test with and without metabolic activation. - Executive summary:
The reverse mutation test with cesium hydroxide was performed on Salmonella typhimurium strains TA100, TA1535, TA98, TA1537, and Escherichia coli strain WP2 uvrA using the pre-incubation method with and without metabolic activation up to a limit concentration of 5000 µg/plate.
The results showed that the number of revertant colonies was less than twice of the negative control for all strains at any dose level with or without metabolic activation. The growth inhibition was observed in all strains at 5000 µg/plate. The positive controls showed a distinct increase of revertant colonies, and the positive controls and the negative controls were within a range of the background data of the laboratory. There were no fluctuations wich might have affected the test results because the sterility test confirmed the absence of micro organisms.
In conclusion, cesium hydroxide was judged to have no reverse mutagenic potenial under the conditions tested.
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