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EC number: 263-047-8 | CAS number: 61789-28-4 A complex combination of hydrocarbons obtained by the distillation of coal tar. It consists primarily of aromatic hydrocarbons and may contain appreciable quantities of tar acids and tar bases. It distills at the approximate range of 200°C to 325°C (392°F to 617°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 Aug. - 03 Sep. 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted 24.2.1987
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Creosote oil, acenaphthene fraction
- EC Number:
- 292-605-3
- EC Name:
- Creosote oil, acenaphthene fraction
- Cas Number:
- 90640-84-9
- IUPAC Name:
- 90640-84-9
- Details on test material:
- - Name of test material (as cited in study report): wash oil
- Molecular formula (if other than submission substance): not applicable
- Molecular weight (if other than submission substance): not applicable
- Substance type: organic
- Physical state: liquid
- Stability under test conditions: WAF (water accommodated fraction) limited
- Storage condition of test material: room temperature, exclusion of light
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: TOP VELAZ s.r.o., Koleč subsidiary
- Age at study initiation: 6 - 7 weeks
- Weight at study initiation: males: 193 g (range: 170 - 208 g) / females: 157 g (range: 150 - 165 g)
- Fasting period before study: ~20 h before treatment
- Housing: conventional, 5 per sex
- Diet: from 30 min post-application
- Water: ad libitum
- Acclimation period: >= 5 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 25
- Humidity (%): 30 - 70
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 2x/d (day 1 and 2), then 1x/d
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- not applicable
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Mortality:
- none
- Clinical signs:
- other: Hunched, lateral or prone posture, apathy, inappetence, cyanotic or pale skin and ischemic mucous membranes recovery within 2 d
- Gross pathology:
- Changes in the lung, more pronounced in female rats: focal emphysema, point-shaped dark-red foci
(indicating to vascular disorder expressed by ischemia peripheric tissues and organs (see lung) probably following a shock-like response).
Any other information on results incl. tables
Table 1: Male body weights (g) – 2000 mg/kg
Animal No. |
Before administration |
Day 8 |
Day 15 |
Increment |
1 |
203.7 |
240.9 |
259.8 |
56.1 |
2 |
186.8 |
214.9 |
237.3 |
50.5 |
3 |
195.5 |
222.8 |
245.7 |
50.2 |
4 |
170.1 |
199.8 |
228.8 |
58.7 |
5 |
207.8 |
238.6 |
267.9 |
60.1 |
Average |
192.8 |
223.4 |
247.9 |
55.1 |
Table 2: Female body weights (g) – 2000 mg/kg
Animal No. |
Before administration |
Day 8 |
Day 15 |
Increment |
1 |
156.3 |
173 |
188.3 |
27 |
2 |
150.4 |
171 |
175.3 |
24.9 |
3 |
158.3 |
172 |
183.1 |
24.8 |
4 |
164.9 |
189 |
205.6 |
40.7 |
5 |
153.2 |
168 |
182.9 |
29.7 |
Average |
156.6 |
174 |
187 |
29.4 |
Table 3: Pathological examination of the male and female rats – 2000 mg/kg
Animal No. |
Autopsy finding |
|
males |
females |
|
1 |
No macroscopic changes |
Lungs – dark-red dot-like foci |
2 |
Lungs – emphysematous foci |
Lungs – emphysematous foci |
3 |
Lungs – dark-red dot-like foci |
Lungs – dark-red dot-like foci |
4 |
No macroscopic changes |
Lungs – dark-red dot-like foci |
5 |
No macroscopic changes |
Lungs – dark-red dot-like foci |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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